THE EFFECTS OF TESTOSTERONE AND NALOXONE TREATMENTS ON FEAR BEHAVIOR IN GONADECTOMIZED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAKPAY F.; PILEHVARIAN A.A.; ROSTAMI P.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:3 Page(s): 211-217

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

905

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF TESTOSTERONE AND NALOXONE TREATMENTS ON FEAR BEHAVIOR IN GONADECTOMIZED RATS

Author(s)

KHAKPAY F. | PILEHVARIAN A.A. | ROSTAMI P. | Issue Writer Certificate

Keywords

GONADECTOMYQ3

TESTOSTERONEQ3

NALOXONEQ3

OPEN ARM ENTRIESQ3

TIME SPENT IN THE OPEN ARMQ3

Abstract

Introduction: Effective perception of fear signals is crucial for organism survival. When threated, the organism indicates defensive behaviors. Methods: Elevated plus-maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. Increase in two parameters; percent of openarm entries (%OAE) and percent of time spent in the open-arm (%OAT) in the elevated plus- maze were considered as the indexes of fear reduction effect. In this study, the effect of TESTOSTERONE and NALOXONE on fear behavior of gonadectomized rats (GDX) was investigated. Also, the interaction of TESTOSTERONE with NALOXONE was investigated. Results: Subcutaneous (SC) injections of different doses of TESTOSTERONE (100,200, 300, 450 mg/rat) increased the %OAE and %OAT in a dose dependent manner. Maximum response was obtained by 450 mg/rat dose of TESTOSTERONE (P<0.001).SC injections of opioid receptors antagonist, NALOXONE 1,2.5,5, 7.5 mg / kg reduced %OAE and %OAT (P<0.01).Conclusion: It may be concluded that TESTOSTERONE decreases fear behavior and NALOXONE increased fear behavior. Also the results indicate that there is an interaction between testosteone and NALOXONE (P<0.001).

Cites

No record.

References

No record.

Cite

APA: Copy

KHAKPAY, F., PILEHVARIAN, A.A., & ROSTAMI, P.. (2006). THE EFFECTS OF TESTOSTERONE AND NALOXONE TREATMENTS ON FEAR BEHAVIOR IN GONADECTOMIZED RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(3), 211-217. SID. https://sid.ir/paper/75075/en

Vancouver: Copy

KHAKPAY F., PILEHVARIAN A.A., ROSTAMI P.. THE EFFECTS OF TESTOSTERONE AND NALOXONE TREATMENTS ON FEAR BEHAVIOR IN GONADECTOMIZED RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(3):211-217. Available from: https://sid.ir/paper/75075/en

IEEE: Copy

F. KHAKPAY, A.A. PILEHVARIAN, and P. ROSTAMI, “THE EFFECTS OF TESTOSTERONE AND NALOXONE TREATMENTS ON FEAR BEHAVIOR IN GONADECTOMIZED RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 3, pp. 211–217, 2006, [Online]. Available: https://sid.ir/paper/75075/en

Related Journal Papers