THE ROLE OF CA1 α-ADRENOCEPTOR ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MALE RATS

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AZAMI N.A.S.; PIRI MORTEZA; JAHANSHAHI MEHRDAD; ORYAN SHAHRBANOU; BABAPOUR V.; ZARRINDASTA M.R.

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Journal: Physiology and Pharmacology Year:2010 | Volume:14 | Issue:1 Page(s): 66-77

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Title

THE ROLE OF CA1 α-ADRENOCEPTOR ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MALE RATS

Author(s)

Keywords

SCOPOLAMINEQ3

α-ADRENERGIC RECEPTORSQ3

DORSAL HIPPOCAMPUSQ3

INHIBITORY AVOIDANCE RESPONSEQ3

STATEDEPENDENT LEARNINGQ3

Abstract

Introduction: Similarities in the memory impairment between Alzheimer patients and SCOPOLAMINE treated animals have been reported. In the present study, the possible role of a-adrenergic receptors of the DORSAL HIPPOCAMPUS on SCOPOLAMINE state-dependent memory in adult male Wistar rats was evaluated.Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS, trained in a step-through type inhibitory avoidance task, and tested 24 h after training to measure stepthrough latency.Results: Post-training intra-CA1 administration of SCOPOLAMINE (0.5 and 2mg/rat) dose-dependently reduced the step-through latency, showing an amnestic response. Amnesia produced by post-training SCOPOLAMINE (2 mg/rat) was reversed by pre-test administration of the SCOPOLAMINE (0.5 and 2 mg/rat) that is due to a state-dependent effect. Pre-test intra-CA1 injection of a1-adrenoceptor agonist, phenylephrine (0.25, 0.5 mg/rat) in the dose range that we used, could not affect memory impairment induced by post-training injection of SCOPOLAMINE (2 mg/rat). However intra-CA1 pretest injection of a2-adrenoceptor agonist, clonidine (0.5 mg/rat) improved post-training SCOPOLAMINE (2 mg/rat) intra- CA1 injection induced retrieval impairment. Furthermore, pre-test intra-CA1 microinjection of phenylephrine (0.25 and 0.5 mg/rat) or clonidine (0.25 and 0.5 mg/rat) with an ineffective dose of SCOPOLAMINE (0.25 mg/rat), synergistically improved memory performance impaired by post-training SCOPOLAMINE (2 mg/rat). Our results also showed that, pre-test injection of a1-receptor antagonist prazosin (1, 2 mg/rat) or a2-receptors antagonist yohimbine (1, 2 mg/rat) before effective dose of SCOPOLAMINE (2 mg/rat) prevented the improvement of memory by pre-test SCOPOLAMINE. Conclusion: These results suggest that a1- and a2-adrenergic receptors of the dorsal hippocampal CA1 region may play an important role in SCOPOLAMINE-induced amnesia and SCOPOLAMINE state-dependent memory.

Cites

THE INHIBITION OF STATE-DEPENDENT LEARNING INDUCED BY SCOPOLAMINE VIA BLOCKADE OF DORSAL HIPPOCAMPAL BETA1-ADRENERGIC RECEPTORS IN RATS

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APA: Copy

AZAMI, N.A.S., PIRI, MORTEZA, JAHANSHAHI, MEHRDAD, ORYAN, SHAHRBANOU, BABAPOUR, V., & ZARRINDASTA, M.R.. (2010). THE ROLE OF CA1 α-ADRENOCEPTOR ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 14(1), 66-77. SID. https://sid.ir/paper/75083/en

Vancouver: Copy

AZAMI N.A.S., PIRI MORTEZA, JAHANSHAHI MEHRDAD, ORYAN SHAHRBANOU, BABAPOUR V., ZARRINDASTA M.R.. THE ROLE OF CA1 α-ADRENOCEPTOR ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2010;14(1):66-77. Available from: https://sid.ir/paper/75083/en

IEEE: Copy

N.A.S. AZAMI, MORTEZA PIRI, MEHRDAD JAHANSHAHI, SHAHRBANOU ORYAN, V. BABAPOUR, and M.R. ZARRINDASTA, “THE ROLE OF CA1 α-ADRENOCEPTOR ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 14, no. 1, pp. 66–77, 2010, [Online]. Available: https://sid.ir/paper/75083/en

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