EVALUATION OF THE EFFECT OF NEUROPATHIC PAIN ON FORMALIN-INDUCED PAIN AND THE EFFECT OF FORMALIN PAIN PRIOR TO NEUROPATHY ON FORMALIN PAIN

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SEDAGHAT K.; MANAHEJI H.

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 143-152

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Title

EVALUATION OF THE EFFECT OF NEUROPATHIC PAIN ON FORMALIN-INDUCED PAIN AND THE EFFECT OF FORMALIN PAIN PRIOR TO NEUROPATHY ON FORMALIN PAIN

Author(s)

SEDAGHAT K. | MANAHEJI H. | Issue Writer Certificate

Keywords

NEUROPATHIC PAINQ4

CHRONIC CONSTRICTION INJURY (CCI)Q3

FORMALIN PAINQ4

HYPERALGESIAQ4

HYPOALGESIAQ4

Abstract

Chronic constriction injury (CCI) is a commonly accepted model of NEUROPATHIC PAIN, which has been introduced by Bennett and Xie in 1988. This model contains the most usual characteristics of human NEUROPATHIC PAIN due to an increase in central sensitization like HYPERALGESIA and allodynia. It is a usual practice to apply acute pain stimulants such as thermal and mechanical ones for assessment of CCL In this experiment, formalin has been used as a chemical stimulant, which produces two phases of acute and chronic pain. In this way, the effect of CCI is not only determined in the acute phase, but also in the chronic phase, which the latter has a different mechanism of development. Furthermore, the role of FORMALIN PAIN prior to CCI on FORMALIN PAIN following CCI was also studied. Moreover, the role of intravenous injection of lidocaine, as a central pain blocker, before injection of formalin prior to CCI and its effect on the FORMALIN PAIN post CCI was also investigated. The results showed that in the first phase of formalin test, CCI produced HYPERALGESIA at second day post CCI in the group which had sciatic ligation without formalin injection prior to CCI and HYPERALGESIA at day 14 post CCI in all groups, with or without formalin injection prior to CCI and the group who had lidocaine. In this respect, there were not any significant changes in the second phase of formalin test in all groups, except for HYPERALGESIA at second day post CCI in the group which had not received formalin prior to CCI.

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APA: Copy

SEDAGHAT, K., & MANAHEJI, H.. (2003). EVALUATION OF THE EFFECT OF NEUROPATHIC PAIN ON FORMALIN-INDUCED PAIN AND THE EFFECT OF FORMALIN PAIN PRIOR TO NEUROPATHY ON FORMALIN PAIN. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 143-152. SID. https://sid.ir/paper/75097/en

Vancouver: Copy

SEDAGHAT K., MANAHEJI H.. EVALUATION OF THE EFFECT OF NEUROPATHIC PAIN ON FORMALIN-INDUCED PAIN AND THE EFFECT OF FORMALIN PAIN PRIOR TO NEUROPATHY ON FORMALIN PAIN. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):143-152. Available from: https://sid.ir/paper/75097/en

IEEE: Copy

K. SEDAGHAT, and H. MANAHEJI, “EVALUATION OF THE EFFECT OF NEUROPATHIC PAIN ON FORMALIN-INDUCED PAIN AND THE EFFECT OF FORMALIN PAIN PRIOR TO NEUROPATHY ON FORMALIN PAIN,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 143–152, 2003, [Online]. Available: https://sid.ir/paper/75097/en

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