CENTRAL MINERALOCORTICOID RECEPTORS MEDIATE IMPAIRING EFFECTS OF CORTICOSTERONE ON MEMORY RETRIEVAL IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAKSARI MAHDI; RASHIDIPOUR A.; VAFAEI ABAS ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2008 | Volume:11 | Issue:4 Page(s): 282-292

Download Full-Text

Persian Verion

View:

1,213

Download:

Cites:

Information Journal Paper

Title

CENTRAL MINERALOCORTICOID RECEPTORS MEDIATE IMPAIRING EFFECTS OF CORTICOSTERONE ON MEMORY RETRIEVAL IN RATS

Author(s)

KHAKSARI MAHDI | RASHIDIPOUR A. | VAFAEI ABAS ALI | Issue Writer Certificate

Keywords

GLUCOCORTICOIDSQ3

MINERALOCORTICOID RECEPTORQ3

GLUCOCORTICOID RECEPTORQ3

SPIRONOLACTONEQ3

RU 38486Q4

ANISOMYCINQ3

MEMORY RETRIEVALQ3

WATER MAZEQ3

Abstract

Introduction: Previous studies have indicated that stress levels of glucocorticoid hormones induce impairment of long term MEMORY RETRIEVAL, but the underlying mechanisms (genomic or non-genomic) are not clear. To clarify this issue, we investigated the involvement of brain corticosteroid receptors and protein synthesis in the glucocorticoid-induced impairment of MEMORY RETRIEVAL.Methods: 140 young rats were trained in the WATER MAZE (WM) task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24 h after the last training session with a 60-s probe trial. Experiments included intraventricular injections of ANISOMYCIN (187.5 or 450mg/5ml), a specific protein synthesis inhibitor or specific antagonists for MINERALOCORTICOID RECEPTORs (MR, 37.5, 75, 150 mg/5ml) or GLUCOCORTICOIDS receptors (GR, 75 or 150mg/5ul) before corticosterone administration (1 mg/kg) shortly before retention testing.Results: The results showed that administration of ANISOMYCIN did not change the corticosterone response. Administration of the MR, but not GR, antagonist blocked the corticosterone-induced response.Conclusion: These findings provide evidence for the view that GLUCOCORTICOIDS impair MEMORY RETRIEVAL through non-genomic mechanisms involving an interaction with central MRs.

Cites

No record.

References

No record.

Cite

APA: Copy

KHAKSARI, MAHDI, RASHIDIPOUR, A., & VAFAEI, ABAS ALI. (2008). CENTRAL MINERALOCORTICOID RECEPTORS MEDIATE IMPAIRING EFFECTS OF CORTICOSTERONE ON MEMORY RETRIEVAL IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(4), 282-292. SID. https://sid.ir/paper/75145/en

Vancouver: Copy

KHAKSARI MAHDI, RASHIDIPOUR A., VAFAEI ABAS ALI. CENTRAL MINERALOCORTICOID RECEPTORS MEDIATE IMPAIRING EFFECTS OF CORTICOSTERONE ON MEMORY RETRIEVAL IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;11(4):282-292. Available from: https://sid.ir/paper/75145/en

IEEE: Copy

MAHDI KHAKSARI, A. RASHIDIPOUR, and ABAS ALI VAFAEI, “CENTRAL MINERALOCORTICOID RECEPTORS MEDIATE IMPAIRING EFFECTS OF CORTICOSTERONE ON MEMORY RETRIEVAL IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 4, pp. 282–292, 2008, [Online]. Available: https://sid.ir/paper/75145/en

Related Journal Papers