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Information Journal Paper

Title

The Comparison of Green Tea Aqueous Extract and Catechin Effect on Pituitary-Gonadal Axis in Rat Models of Type 1 Diabetes

Pages

  9-15

Abstract

 Background & Objective: Diabetes causes fertility disorders by interfering with the endocrine gland function. There are reports that, Green tea and Catechins could have anti-oxidant and hypoglycemic properties. Therefore, in the present study, we evaluated the effects of Green tea aqueous extract and Catechin influence on pituitary-gonadal axis in rat models of type 1 diabetes. Materials & Methods: Six groups of Wistar Rats (8 in each group), including control, diabetic control (intraperitoneal injection (IP) of 0. 5 mL saline solution for 30 days after induction of diabetes), diabetic treated with 100 and 200 mg/kg doses of Green tea aqueous extract (IP injection of 0. 5 mL Green tea extract for 30 days), and diabetic treated with 100 and 200 mg/kg doses of Catechin (IP injection 0. 5 mL of Catechin for 30 days) were used. The induction of diabetes was conducted through an IP injection of 240 mg/kg alloxan. At the end of the treatment course, the serum levels of LH, FSH, estrogen, testosterone, dihydrotestosterone and cytoplasmic HOdG-8 in testicular tissue were measured by ELISA method. ANOVA and Tukey post hoc test (P<0. 05) were used to perform the data analysis. Results: The incorporation of 200 mg/kg Green tea extract and 100 and 200 mg/kg concentrations of Catechin, in comparison with the diabetic control group, led to a significant dose-dependent increase in the serum level of LH, FSH, estrogen, testosterone, and dihydrotestosterone. A dose-dependent significant decrease was observed in HOdG-8 in the testicular tissue of diabetic Rats (P<0. 05). Conclusion: Based on the obtained data, compared to Green tea, Catechin considerably enhanced the hormonal parameters and reduced HOdG-8 in testicular tissue of diabetic Rats.

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    Cite

    APA: Copy

    Noori Roshnavand, Fatemeh, HOJATI, VIDA, VAEZI, GHOLAMHASSAN, & Rahbarian, Raheleh. (2019). The Comparison of Green Tea Aqueous Extract and Catechin Effect on Pituitary-Gonadal Axis in Rat Models of Type 1 Diabetes. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 27(125), 9-15. SID. https://sid.ir/paper/751460/en

    Vancouver: Copy

    Noori Roshnavand Fatemeh, HOJATI VIDA, VAEZI GHOLAMHASSAN, Rahbarian Raheleh. The Comparison of Green Tea Aqueous Extract and Catechin Effect on Pituitary-Gonadal Axis in Rat Models of Type 1 Diabetes. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2019;27(125):9-15. Available from: https://sid.ir/paper/751460/en

    IEEE: Copy

    Fatemeh Noori Roshnavand, VIDA HOJATI, GHOLAMHASSAN VAEZI, and Raheleh Rahbarian, “The Comparison of Green Tea Aqueous Extract and Catechin Effect on Pituitary-Gonadal Axis in Rat Models of Type 1 Diabetes,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 27, no. 125, pp. 9–15, 2019, [Online]. Available: https://sid.ir/paper/751460/en

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