EFFECT OF CO-ADMINISTERATION OF NITRIC OXIDE AND MORPHINE INTO CA3 REGION OF HIPPOCAMPUS ON LEARNING AND SPATIAL MEMORY IN MORPHINE DEPENDENT MALE RATS

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POURABOULI IRAN; ABBASNEZHAD MAHDI; POURABOULI BATOUL; YOUSEFI AHMAD

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Journal: Physiology and Pharmacology Year:2008 | Volume:11 | Issue:4 Page(s): 293-299

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Title

EFFECT OF CO-ADMINISTERATION OF NITRIC OXIDE AND MORPHINE INTO CA3 REGION OF HIPPOCAMPUS ON LEARNING AND SPATIAL MEMORY IN MORPHINE DEPENDENT MALE RATS

Author(s)

POURABOULI IRAN | ABBASNEZHAD MAHDI | POURABOULI BATOUL | YOUSEFI AHMAD | Issue Writer Certificate

Keywords

LEARNINGQ2

SPATIAL MEMORYQ3

MORPHINE DEPENDENCYQ3

HIPPOCAMPUSQ3

NOQ3

Abstract

Introduction: The effect of MORPHINE DEPENDENCY on LEARNING and SPATIAL MEMORY is controversial. In this study, the effect of co-administration of nitric oxide (NO) and morphine in CA3 region of HIPPOCAMPUS on LEARNING and SPATIAL MEMORY in morphine dependent rats was investigated.Methods: After anaesthetizing of male rats, guide cannula was implanted bilaterally in CA3 region of HIPPOCAMPUS. After recovery period (7 days), MORPHINE DEPENDENCY was induced then animals divided to 6 groups and respectively received 1ml saline, L-Arginine, L-Name, morphine, L-Arginine+morphine and/or L-Name+morphine. MORPHINE DEPENDENCY was induced by subcutaneous injections of morphine (10 mg/kg first day and 20 mg/kg for four next days). During Morris water maze test period, last dose of morphine (20 mg/kg) was injected daily to maintain MORPHINE DEPENDENCY.Results: L-Name decreased LEARNING in morphine dependent rats but it was NOt effective on retention of memory. Morphine did NOt affect LEARNING and SPATIAL MEMORY. Co-administration of L-Arginine and morphine promoted the effect of L-Arginine on LEARNING and SPATIAL MEMORY.Conclusion: It seems that comparing to separate administration, co-administration of NO and morphine in morphine dependent rats does a better improvement in LEARNING and SPATIAL MEMORY.

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APA: Copy

YOUSEFI, AHMAD, POURABOULI, IRAN, ABBASNEZHAD, MAHDI, & POURABOULI, BATOUL. (2008). EFFECT OF CO-ADMINISTERATION OF NITRIC OXIDE AND MORPHINE INTO CA3 REGION OF HIPPOCAMPUS ON LEARNING AND SPATIAL MEMORY IN MORPHINE DEPENDENT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(4), 293-299. SID. https://sid.ir/paper/75148/en

Vancouver: Copy

YOUSEFI AHMAD, POURABOULI IRAN, ABBASNEZHAD MAHDI, POURABOULI BATOUL. EFFECT OF CO-ADMINISTERATION OF NITRIC OXIDE AND MORPHINE INTO CA3 REGION OF HIPPOCAMPUS ON LEARNING AND SPATIAL MEMORY IN MORPHINE DEPENDENT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;11(4):293-299. Available from: https://sid.ir/paper/75148/en

IEEE: Copy

AHMAD YOUSEFI, IRAN POURABOULI, MAHDI ABBASNEZHAD, and BATOUL POURABOULI, “EFFECT OF CO-ADMINISTERATION OF NITRIC OXIDE AND MORPHINE INTO CA3 REGION OF HIPPOCAMPUS ON LEARNING AND SPATIAL MEMORY IN MORPHINE DEPENDENT MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 4, pp. 293–299, 2008, [Online]. Available: https://sid.ir/paper/75148/en

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