Comparison of 2 Naltrexone Regimens in the Maintenance Therapy of Acute Methadone Overdose in Opioid-Naï ve Patients: A Randomized Controlled Trial

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OSTADI ALI; ZAMANI NASIM; HASSANIAN MOGHADDAM HOSSEIN; KHOSRAVI NAVID; SHADNIA SHAHIN

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Journal: Crescent Journal of Medical and Biological Sciences Year:2019 | Volume:6 | Issue:1 Page(s): 1-5

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Title

Comparison of 2 Naltrexone Regimens in the Maintenance Therapy of Acute Methadone Overdose in Opioid-Naï ve Patients: A Randomized Controlled Trial

Author(s)

Keywords

Methadone

Overdose

Intoxication

Opioid-naïve

Naltrexone

Abstract

Objectives: Substituting antidotes with longer half-lives may decrease the danger of unobserved respiratory depression in opioid Overdose. The present triple-blind controlled trial aimed to compare two different doses of Naltrexone (i. e., 50 vs. 100 mg) in the maintenance therapy regarding Methadone-Overdosed in opioid-naï ve patients. Materials and Methods: Seventy opioid-naï ve Methadone-intoxicated patients with a mean age of 26 ± 9 years were prospectively included in this study and were treated with naloxone. They were then consecutively assigned to A or B groups (including 35 patients each) receiving 100-and 50-mg Naltrexone capsules, respectively. The patients were followed for 48 hours in the hospital and re-evaluated by a phone call follow-up after discharge. Finally, they were compared regarding re-development of the toxicity signs and symptoms, a need for re-administration of naloxone, and the final outcome. Results: Based on the results, only diastolic blood pressure, serum bicarbonate, and base excess were significantly different between the groups. During hospitalization, one patient in group A experienced apnea while none of the patients in group B had such an experience (P > 0. 05). In addition, in follow-up evaluations and after the hospital discharge, the mean venous blood gas (VBG) parameters were found to be identical between both groups. Hospitalization period was similar (all P values were greater than 0. 05). Conclusions: In general, 2 different 50-and 100-mg regimens of Naltrexone have the same efficacy in preventing the apnea and respiratory depression in Methadone-intoxicated opioid-naï ve patients. However, the 50-mg dose is the superior regimen recommended in this respect.

Cites

Safety of Naloxone in Opioid-Naive Methadone Intoxicated Patients; a Case Series Study

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APA: Copy

OSTADI, ALI, ZAMANI, NASIM, HASSANIAN MOGHADDAM, HOSSEIN, KHOSRAVI, NAVID, & SHADNIA, SHAHIN. (2019). Comparison of 2 Naltrexone Regimens in the Maintenance Therapy of Acute Methadone Overdose in Opioid-Naï ve Patients: A Randomized Controlled Trial. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 6(1), 1-5. SID. https://sid.ir/paper/752173/en

Vancouver: Copy

OSTADI ALI, ZAMANI NASIM, HASSANIAN MOGHADDAM HOSSEIN, KHOSRAVI NAVID, SHADNIA SHAHIN. Comparison of 2 Naltrexone Regimens in the Maintenance Therapy of Acute Methadone Overdose in Opioid-Naï ve Patients: A Randomized Controlled Trial. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2019;6(1):1-5. Available from: https://sid.ir/paper/752173/en

IEEE: Copy

ALI OSTADI, NASIM ZAMANI, HOSSEIN HASSANIAN MOGHADDAM, NAVID KHOSRAVI, and SHAHIN SHADNIA, “Comparison of 2 Naltrexone Regimens in the Maintenance Therapy of Acute Methadone Overdose in Opioid-Naï ve Patients: A Randomized Controlled Trial,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 6, no. 1, pp. 1–5, 2019, [Online]. Available: https://sid.ir/paper/752173/en

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