EFFECT OF INTRA-CA1 INJECTION OF ESTROGEN ON SPATIAL MEMORY AND LEARNING IN RATS

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MORADPOUR F.; NAGHDI N.; FATH ELAHI Y.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:3 Page(s): 159-169

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Title

EFFECT OF INTRA-CA1 INJECTION OF ESTROGEN ON SPATIAL MEMORY AND LEARNING IN RATS

Author(s)

MORADPOUR F. | NAGHDI N. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

ESTRADIOL VALERATEQ3

ANASTRAZOLEQ3

HIPPOCAMPUSQ3

MEMORY & LEARNINQ3

Abstract

Introduction: Sex hormones are one of the most important factors responsible for differences of learning and memory between males and females. High concentration of estrogen and androgen receptors and mechanism of testosterone and estrogen production in learning and memory center, especially in HIPPOCAMPUS show the role of these receptors, sex hormones and P450 enzymes in spatial memory. In this study we evaluated the effect of ESTRADIOL VALERATE (BV) and an aromatase inhibitor, anasterazole (An), on spatial learning and memory in Morris Water Maze. Methods: Adult male rats were bilaterally cannulated into the CAI region. After the recovery period, control groups received either DMSO 0.5 ml or DMSO 0.5 ml+ 0.5 ml. Different doses of EV (1, 2.5, 5, 10 and 15 mg/ 0.5 ml), An (0.25, 0.5 and mg/ 0.5 ml)and EV 15 mg/ 0.5 m1+ An 0.5 m/0.5ml were microinjected every day before training. EV and an were injected 30-35 min and 25-30 min before training, respectively. Results: Our results showed that escape latency and traveled distance were increased in EV 0.15 ml/ 0.5 ml group. We also observed that an decreased escape latency and traveled distance in a dose-dependent manner. Conclusion: EV impaired acquisition of spatial learning and memory but An improved it. However, when An and EV were administered together, An could not prevent EV-induced impairments.

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APA: Copy

MORADPOUR, F., NAGHDI, N., & FATH ELAHI, Y.. (2008). EFFECT OF INTRA-CA1 INJECTION OF ESTROGEN ON SPATIAL MEMORY AND LEARNING IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(3), 159-169. SID. https://sid.ir/paper/75241/en

Vancouver: Copy

MORADPOUR F., NAGHDI N., FATH ELAHI Y.. EFFECT OF INTRA-CA1 INJECTION OF ESTROGEN ON SPATIAL MEMORY AND LEARNING IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(3):159-169. Available from: https://sid.ir/paper/75241/en

IEEE: Copy

F. MORADPOUR, N. NAGHDI, and Y. FATH ELAHI, “EFFECT OF INTRA-CA1 INJECTION OF ESTROGEN ON SPATIAL MEMORY AND LEARNING IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 3, pp. 159–169, 2008, [Online]. Available: https://sid.ir/paper/75241/en

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