THE EFFECT OF RESTRAINT STRESS ON WITHDRAWAL SYNDROME SIGNS IN MICE

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POURMOTEABED A.R.; HAGHIGHIZAD H.; AZIZKHAN F.

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Journal: Physiology and Pharmacology Year:2004 | Volume:8 | Issue:1 Page(s): 23-30

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Title

THE EFFECT OF RESTRAINT STRESS ON WITHDRAWAL SYNDROME SIGNS IN MICE

Author(s)

POURMOTEABED A.R. | HAGHIGHIZAD H. | | AZIZKHAN F. | Issue Writer Certificate

Keywords

RESTRAINT STRESSQ4

WITHDRAWAL SYNDROMEQ4

MORPHINEQ3

MICEQ3

Abstract

It has been shown that swimming stress and glucocorticoid injection significantly decrease the WITHDRAWAL SYNDROME signs of opioids in MICE. In the current study, the effect of RESTRAINT STRESS on WITHDRAWAL SYNDROME signs was investigated in MORPHINE-dependent MICE. The experimental strategy of this study was performed on four groups of randomly divided rats;i.e., group A, which received normal saline (negative control), group B receiving MORPHINE (positive control), group C, which received MORPHINE after stress, and group D, which received MORPHINE and stress at the same time. Animals in groups C and D were kept in restrainer for 7 consecutive days (4h/day). Data were subjected to the t test and one-way ANOVA and followed by Tukey test for multiple comparisons. The results showed that a significant reduction in stool weight occur in group D (0.48 ± 0.12 g) in comparison with group B (1.14 ±.0.23 g) respectively (p<0.05). However, no significant change in stool weight was observed comparing groups B and C. In addition, no significant change was observed in the number of jumping among groups B, C, and D.It can be concluded that RESTRAINT STRESS exerts short-term inhibitory effect on MORPHINE action in gastrointestinal tract. The mechanism (s) underling this phenomenon remains to be elucidated.

Cites

EFFECT OF STRESS ON MORPHINE WITHDRAWAL SIGNS IN RATS

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APA: Copy

POURMOTEABED, A.R., HAGHIGHIZAD, H., & AZIZKHAN, F.. (2004). THE EFFECT OF RESTRAINT STRESS ON WITHDRAWAL SYNDROME SIGNS IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 8(1), 23-30. SID. https://sid.ir/paper/75277/en

Vancouver: Copy

POURMOTEABED A.R., HAGHIGHIZAD H., AZIZKHAN F.. THE EFFECT OF RESTRAINT STRESS ON WITHDRAWAL SYNDROME SIGNS IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;8(1):23-30. Available from: https://sid.ir/paper/75277/en

IEEE: Copy

A.R. POURMOTEABED, H. HAGHIGHIZAD, and F. AZIZKHAN, “THE EFFECT OF RESTRAINT STRESS ON WITHDRAWAL SYNDROME SIGNS IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 1, pp. 23–30, 2004, [Online]. Available: https://sid.ir/paper/75277/en

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