THE EFFECT OF ESTRADIOL VALERATE AND ETHINYL ESTRADIOL ON SERUM LIPIDS AND LIPOPROTEINS OF FEMALE RATS

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VAHDATI A.; SARIRIAN R.; AFROUZ T.

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Journal: Physiology and Pharmacology Year:2004 | Volume:8 | Issue:1 Page(s): 101-106

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Title

THE EFFECT OF ESTRADIOL VALERATE AND ETHINYL ESTRADIOL ON SERUM LIPIDS AND LIPOPROTEINS OF FEMALE RATS

Author(s)

VAHDATI A. | SARIRIAN R. | AFROUZ T. | Issue Writer Certificate

Keywords

ESTROGENQ2

LIPIDSQ4

LIPOPROTEINSQ3

RATQ4

Abstract

ESTROGEN as a female sex hormone involved in reproductive system has also many important metabolic effects. This hormone could exert beneficial protective effect on the cardiovascular system of women. This protective effect is due to its effects on liver and plasma LIPIDS and LIPOPROTEINS. In this study, the effect of two different doses of estradiol and ethinyl estradiol valerate on concentrations of serum LIPIDS and LIPOPROTEINS in female RATs (n = 30) were investigated. For this purpose, two concentrations (0.1 and 1 mg/ml) of hormones were prepared. Thereafter, 4 different test groups were daily injected with 0.2 ml of one concentration. The control group received only 0.2 ml of sesame oil. Estradiol was injected subcutaneously daily for two months. During all experiments, RATs received normal standard pelleted food. Finally, blood samples were taken and the concentrations of total cholesterol, triglyceride, VLDL, HDL and LDL were measured using autoanalyzer. The results suggested that ethinyl estradiol and estradiol valerate may decrease concentrations of the serum total cholesterol and LDL. It was also indicated that ethinyl estradiol increases the concentrations of serum triglyceride and VLDL, but none of them have any effect on serum HDL concentration.

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APA: Copy

VAHDATI, A., SARIRIAN, R., & AFROUZ, T.. (2004). THE EFFECT OF ESTRADIOL VALERATE AND ETHINYL ESTRADIOL ON SERUM LIPIDS AND LIPOPROTEINS OF FEMALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 8(1), 101-106. SID. https://sid.ir/paper/75280/en

Vancouver: Copy

VAHDATI A., SARIRIAN R., AFROUZ T.. THE EFFECT OF ESTRADIOL VALERATE AND ETHINYL ESTRADIOL ON SERUM LIPIDS AND LIPOPROTEINS OF FEMALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;8(1):101-106. Available from: https://sid.ir/paper/75280/en

IEEE: Copy

A. VAHDATI, R. SARIRIAN, and T. AFROUZ, “THE EFFECT OF ESTRADIOL VALERATE AND ETHINYL ESTRADIOL ON SERUM LIPIDS AND LIPOPROTEINS OF FEMALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 1, pp. 101–106, 2004, [Online]. Available: https://sid.ir/paper/75280/en

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