AN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA FOLLOWING OCCLUSION OF MIDDLE CEREBRAL ARTERY IN RAT

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VAKILI ABEDIN; DEHGHAN G.A.; NEKOUEIAN A.A.

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Journal: Physiology and Pharmacology Year:2004 | Volume:8 | Issue:1 Page(s): 3-12

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Title

AN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA FOLLOWING OCCLUSION OF MIDDLE CEREBRAL ARTERY IN RAT

Author(s)

VAKILI ABEDIN | DEHGHAN G.A. | NEKOUEIAN A.A. | Issue Writer Certificate

Keywords

FOCAL CEREBRAL ISCHEMIAQ4

MIDDLE CEREBRAL ARTERYQ4

RATQ3

Abstract

Middle cerebral artery occlusion (MCAO) is the most common cause of FOCAL CEREBRAL ISCHEMIA (FCI) in mankind. Experimental induction of MCAO in animals can elucidate the role of neural substances released from damaged cells of the infarct region and to evaluate drug interactions for reducing the infarct volume. For this purpose, FOCAL CEREBRAL ISCHEMIA was produced in 21 male RATs weighing 300-400 g. The RATs were anesthetized using chloral hydrate (400 mg/kg, i.p.). After performing a general surgical operation, right common carotid artery was exposed up to its bifurcation to external and internal arteries. Then, a 90-min MCAO was achieved by advancing a nylon thread via internal carotid artery up to the level of MIDDLE CEREBRAL ARTERY, followed by reperfusion. After 24 h, standard neurological examinations (NS) were performed. Finally, the animals were decapitated to remove the brains and prepare them for the measurement of infarct volume using histological techniques and microscopic evaluation. The results of this study indicated that MCAO intraluminal technique induces a consistent FOCAL CEREBRAL ISCHEMIA in the RAT, and hence, can be used as a reliable technique to investigate the neurotoxic and neuroprotective actions of chemical substances released from damaged cells from the ischemic regions of damaged brains, and to analyze the involved pathophysiological mechanisms after reperfusion.

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APA: Copy

VAKILI, ABEDIN, DEHGHAN, G.A., & NEKOUEIAN, A.A.. (2004). AN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA FOLLOWING OCCLUSION OF MIDDLE CEREBRAL ARTERY IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 8(1), 3-12. SID. https://sid.ir/paper/75281/en

Vancouver: Copy

VAKILI ABEDIN, DEHGHAN G.A., NEKOUEIAN A.A.. AN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA FOLLOWING OCCLUSION OF MIDDLE CEREBRAL ARTERY IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;8(1):3-12. Available from: https://sid.ir/paper/75281/en

IEEE: Copy

ABEDIN VAKILI, G.A. DEHGHAN, and A.A. NEKOUEIAN, “AN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA FOLLOWING OCCLUSION OF MIDDLE CEREBRAL ARTERY IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 1, pp. 3–12, 2004, [Online]. Available: https://sid.ir/paper/75281/en

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