THE INVOLVEMENT OF GABAERGIC AND GLUTAMATERGIC SYSTEMS OF HORIZONTAL LIMB OF DIAGONAL BAND OF BROCA IN THE REGULATION OF BLOOD PRESSURE AND HEART RATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HATAM M.; NASIMI A.; BORJIAN L.; ALAEI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2004 | Volume:8 | Issue:1 Page(s): 49-60

Download Full-Text

Persian Verion

View:

1,122

Download:

Cites:

Information Journal Paper

Title

THE INVOLVEMENT OF GABAERGIC AND GLUTAMATERGIC SYSTEMS OF HORIZONTAL LIMB OF DIAGONAL BAND OF BROCA IN THE REGULATION OF BLOOD PRESSURE AND HEART RATE

Author(s)

HATAM M. | NASIMI A. | BORJIAN L. | ALAEI H. | Issue Writer Certificate

Keywords

DIAGONAL BAND OF BROCAQ4

GABAQ4

GLUTAMATEQ3

BLOOD PRESSUREQ3

HEART RATEQ4

Abstract

DIAGONAL BAND OF BROCA (DBB) is part of the limbic system with involvement in cardiovascular regulation. It has recently been shown that microinjection of L-glutamate into horizontal limb of this region (hDB) elicits cardiovascular depressive responses. This area also contains a large population of GABAergic neurons. In this research study, the cardiovascular responses elicited by GLUTAMATE and GABA (GABAA receptor) systems of hDB were evaluated. Experiments were performed on 36 anesthetized and artificially ventilated rats. Drugs were microinjected into hDB at a volume of 50 nl. BLOOD PRESSURE and HEART RATE were recorded before and at different time points after each experiment. The average changes in the mean arterial pressure and HEART RATE at different intervals were compared using Repeated Measures ANOVA.The results showed that microinjection of 50 nl of L-glutamate (0.25 M) into hDB decrease mean arterial pressure (24.4±3.7 mmHg) and HEART RATE (25.2±3.8 bpm). In addition, injection of AP5 (1 and 5 mM) as an antagonist of GLUTAMATE NMDA receptors and CNQX (0.5 and ImM) as an antagonist of GLUTAMATE AMPA receptors had no significant effect on the mean arterial pressure and HEART RATE. On the other hand, microinjection of GABAA receptor antagonist bicuculline (1 nmM) increased both the mean arterial pressure and HEART RATE (p<0.01), and musimol as a GABAA agonist (500 pM) significantly decreased both mean arterial pressure and HEART RATE (p<0.01).These results demonstrated that stimulation of the GLUTAMATErgic system leads to a reduction in BLOOD PRESSURE and HEART RATE, which was similar to previous findings, while inhibition of NMDA and AMPA receptors has no significant effect on these parameters.Furthermore, stimulation of GABAA receptors could reduce BLOOD PRESSURE and HEART RATE and their inhibition is accompanied with a rise in these parameters.

Cites

No record.

References

No record.

Cite

APA: Copy

HATAM, M., NASIMI, A., BORJIAN, L., & ALAEI, H.. (2004). THE INVOLVEMENT OF GABAERGIC AND GLUTAMATERGIC SYSTEMS OF HORIZONTAL LIMB OF DIAGONAL BAND OF BROCA IN THE REGULATION OF BLOOD PRESSURE AND HEART RATE. PHYSIOLOGY AND PHARMACOLOGY, 8(1), 49-60. SID. https://sid.ir/paper/75284/en

Vancouver: Copy

HATAM M., NASIMI A., BORJIAN L., ALAEI H.. THE INVOLVEMENT OF GABAERGIC AND GLUTAMATERGIC SYSTEMS OF HORIZONTAL LIMB OF DIAGONAL BAND OF BROCA IN THE REGULATION OF BLOOD PRESSURE AND HEART RATE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;8(1):49-60. Available from: https://sid.ir/paper/75284/en

IEEE: Copy

M. HATAM, A. NASIMI, L. BORJIAN, and H. ALAEI, “THE INVOLVEMENT OF GABAERGIC AND GLUTAMATERGIC SYSTEMS OF HORIZONTAL LIMB OF DIAGONAL BAND OF BROCA IN THE REGULATION OF BLOOD PRESSURE AND HEART RATE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 1, pp. 49–60, 2004, [Online]. Available: https://sid.ir/paper/75284/en

Related Journal Papers