THE EFFECT OF ANTI-PLASMINOGEN MONOCLONAL ANTIBODY ON ANGIOGENESIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MANSOURI K.; MALEKI A.; MIRSHAHI M.; POURFATH ELAH A.A.; ZAHIR MOHAMMAD HASSAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2005 | Volume:9 | Issue:1 Page(s): 63-67

Download Full-Text

Persian Verion

View:

1,150

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ANTI-PLASMINOGEN MONOCLONAL ANTIBODY ON ANGIOGENESIS

Author(s)

Keywords

ANGIOGENESISQ2

PLASMINOGENQ3

MONOCLONAL ANTIBODYQ2

Abstract

ANGIOGENESIS is a complex process during which new blood vessels are generated from the pre-existing vessels. This phenomenon plays an important role in embryonic growth, tissue repair, pathological processes including tumor growth, and so forth. In this respect, the development of tumors is dependent upon new vessel formation to provide enough nutrient and oxygen.Considering the involvement of many factors in ANGIOGENESIS, this study was conducted to evaluate the effect of anti-plasminogen MONOCLONAL ANTIBODY MC2B8 on ANGIOGENESIS. For this purpose, an in vitro model of ANGIOGENESIS was designed using fibrin gel and its covering of endothelial cells of bone marrow capillaries as a three-dimensional structure for endothelial cell growth. Then, different titers of MONOCLONAL ANTIBODY MC2B8 (30-480µg/ml) was added to fibrin gel. The fractions were collected n, 3-5 days after culturing of endothelial cells, growth and migration of cells and ensuing capillary development was microscopically observed. The results showed that addition of MC2B8 delays clot lysis and inhibits ANGIOGENESIS.These findings suggest that the inhibitory effect of MC2B8 on ANGIOGENESIS is possibly mediated through blockade or induction of conformational changes in PLASMINOGEN epitopes that are involved in ANGIOGENESIS and fibrinolysis.

Cites

No record.

References

No record.

Cite

APA: Copy

MANSOURI, K., MALEKI, A., MIRSHAHI, M., POURFATH ELAH, A.A., & ZAHIR, MOHAMMAD HASSAN. (2005). THE EFFECT OF ANTI-PLASMINOGEN MONOCLONAL ANTIBODY ON ANGIOGENESIS. PHYSIOLOGY AND PHARMACOLOGY, 9(1), 63-67. SID. https://sid.ir/paper/75288/en

Vancouver: Copy

MANSOURI K., MALEKI A., MIRSHAHI M., POURFATH ELAH A.A., ZAHIR MOHAMMAD HASSAN. THE EFFECT OF ANTI-PLASMINOGEN MONOCLONAL ANTIBODY ON ANGIOGENESIS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2005;9(1):63-67. Available from: https://sid.ir/paper/75288/en

IEEE: Copy

K. MANSOURI, A. MALEKI, M. MIRSHAHI, A.A. POURFATH ELAH, and MOHAMMAD HASSAN ZAHIR, “THE EFFECT OF ANTI-PLASMINOGEN MONOCLONAL ANTIBODY ON ANGIOGENESIS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 9, no. 1, pp. 63–67, 2005, [Online]. Available: https://sid.ir/paper/75288/en

Related Journal Papers