ASSISTANT OF THE ANTIDEPRESSANT EFFECT OF ROSA CANINA L. PETAL EXTRACTS IN MICE BY FORCED SWIMMING STRESS MODEL

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JAFARI FATEMEH; KHOSRAVI MARYAM; NAJAFI ABEDI AKRAM; SAHRAEI HEDAYAT; RANJBARAN MINA; AMOOEI NASRIN; JALILI CYRUS; BAGHERPOOR MARYAM

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Journal: Physiology and Pharmacology Year:2013 | Volume:17 | Issue:2 Page(s): 232-239

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Title

ASSISTANT OF THE ANTIDEPRESSANT EFFECT OF ROSA CANINA L. PETAL EXTRACTS IN MICE BY FORCED SWIMMING STRESS MODEL

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Keywords

DEPRESSIONQ2

FORCED SWIMMING TESTQ2

ROSA CANINA EXTRACTQ2

Abstract

Introduction: Rosa Damasca essential oil is currently used as anti-depressant in animal models and human. Considering the similarities betweenRosa Canina and Rosa Damasca, the effects of water and alcoholic extracts of R. Caninaon DEPRESSION induced by FORCED SWIMMING TEST (FST) in mice were investigated.Methods: Male NMRI mice (25-30 g) were used (n=6/group). Intraperitoneal injections of alcoholic (5, 10, 20, 30, and 40 mg/kg) and/or water (10, 20 and 30 mg/kg) extracts were administered to the animals 30 min before the FS.Intracerebroventricular injections of the alcoholic and water extracts (1, 5 and 10 mg/mice) to the animals were performed 5 min before FST.Results: Both intraperitoneal (20 and 30 mg/kg) and intracerebroventricular (5, 10 mg/Mouse) injections of R.CaninaL. water extract dose-dependently reduced the animals immobilization, which was similar to the fluoxetine effect. However, the alcoholic extract of R. Canina L. did not change the immobility time in the animals when used intraperitoneally and intracerebroventricularly.Conclusion: It could be concluded that the water extract of R.Canina can inhibit DEPRESSION induced by FST in mice. Since there are some components in the extract that can interact with D2 dopamine receptors in the brain, it is likely that the extract induced its antidepressant effects via such mechanism.

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APA: Copy

JAFARI, FATEMEH, KHOSRAVI, MARYAM, NAJAFI ABEDI, AKRAM, SAHRAEI, HEDAYAT, RANJBARAN, MINA, AMOOEI, NASRIN, JALILI, CYRUS, & BAGHERPOOR, MARYAM. (2013). ASSISTANT OF THE ANTIDEPRESSANT EFFECT OF ROSA CANINA L. PETAL EXTRACTS IN MICE BY FORCED SWIMMING STRESS MODEL. PHYSIOLOGY AND PHARMACOLOGY, 17(2), 232-239. SID. https://sid.ir/paper/75316/en

Vancouver: Copy

JAFARI FATEMEH, KHOSRAVI MARYAM, NAJAFI ABEDI AKRAM, SAHRAEI HEDAYAT, RANJBARAN MINA, AMOOEI NASRIN, JALILI CYRUS, BAGHERPOOR MARYAM. ASSISTANT OF THE ANTIDEPRESSANT EFFECT OF ROSA CANINA L. PETAL EXTRACTS IN MICE BY FORCED SWIMMING STRESS MODEL. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2013;17(2):232-239. Available from: https://sid.ir/paper/75316/en

IEEE: Copy

FATEMEH JAFARI, MARYAM KHOSRAVI, AKRAM NAJAFI ABEDI, HEDAYAT SAHRAEI, MINA RANJBARAN, NASRIN AMOOEI, CYRUS JALILI, and MARYAM BAGHERPOOR, “ASSISTANT OF THE ANTIDEPRESSANT EFFECT OF ROSA CANINA L. PETAL EXTRACTS IN MICE BY FORCED SWIMMING STRESS MODEL,” PHYSIOLOGY AND PHARMACOLOGY, vol. 17, no. 2, pp. 232–239, 2013, [Online]. Available: https://sid.ir/paper/75316/en

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