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Information Journal Paper

Title

Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles

Pages

  77-84

Abstract

 Purpose: The Size of polymeric Nanoparticles is considered as an effective factor in cancer therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was to investigate the effective parameters on poly(lactic-co-glycolic acid)-Paclitaxel (PLGA – PTX) Nanoparticles Size. Methods: We prepared PLGA-PTX Nanoparticles via single emulsion and precipitation methods with variable paremeters including drug concentration, aqueous to organic phase volume ratio, polymer concentration, sonication time and PVA concentration. Results: PLGA-PTX Nanoparticles were characterized by dynamic light scattering (DLS) and scanning electron microscopy (SEM). The results exhibited that the diameter of Nanoparticles enhanced with increasing drug, polymer and PVA concentrations whereas organic to aqueous phase volume ratio and sonication time required to the optimization for a given Size. Conclusion: The precipitation method provides smaller Nanoparticles compared to emulsion one. Variable parameters including drug concentration, aqueous to organic phase volume ratio, polymer concentration, sonication time and PVA concentration affect diameter of Nanoparticles.

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    APA: Copy

    MADANI, FATEMEH, Esnaashari, Seyedeh Sara, MUJOKORO, BASIL, DORKOOSH, FARID, KHOSRAVANI, MASOOD, & ADABI, MAHDI. (2018). Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles. ADVANCED PHARMACEUTICAL BULLETIN, 8(1), 77-84. SID. https://sid.ir/paper/753228/en

    Vancouver: Copy

    MADANI FATEMEH, Esnaashari Seyedeh Sara, MUJOKORO BASIL, DORKOOSH FARID, KHOSRAVANI MASOOD, ADABI MAHDI. Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(1):77-84. Available from: https://sid.ir/paper/753228/en

    IEEE: Copy

    FATEMEH MADANI, Seyedeh Sara Esnaashari, BASIL MUJOKORO, FARID DORKOOSH, MASOOD KHOSRAVANI, and MAHDI ADABI, “Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 1, pp. 77–84, 2018, [Online]. Available: https://sid.ir/paper/753228/en

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