High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseas

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Mozayeni Farnaz; REZAEE SEYED ABDOLRAHIM; JABBARI AZAD FARAHZAD; Shabestari Mahmoud; Faridhosseini Reza; RAFATPANAH HOUSHANG; YOUSEFZADEH HADIS; Garivani Yousef Ali; JARAHI LIDA; VALIZADEH NARGES; Sabet Faezah; Moshirahmadi Sharare; Mohammadi Fatemeh Sadat; Shabestari Mohammad

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Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:4 Page(s): 500-506

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Title

High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseas

Author(s)

Keywords

Cardiac involvement

Coronary artery disease

HTLV-1

HTLV-1 Proviral load

Real-time PCR

Abstract

Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on Cardiac involvement in an endemic region of northeastern Iran. Materials and Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary angiography. A Real-time PCR, TaqMan method, to quantify HTLV-1 proviral load (PVL), and routine hematological and biochemical tests were performed for study subjects. Results: Twenty nine patients were HTLV-1+CAD+ and 13 cases were HTLV-1+CAD-. Although, there were no significant differences for risk factors like FBS, HDL, triglyceride, systolic and diastolic blood pressure (Cbp, Dbp), waist circumference (WC), hip circumference (WL), cholesterol (P=0. 003), and LDL (P=0. 007) levels, and monocyte count (P=0. 05) had meaningful differences. The mean HTLV-1 PVL in HTLV-1+CAD+ subjects was 992. 62± 120 which was higher compared with HTLV-1+CAD-group (406. 54± 302 copies/104 PBMCs). Moreover, HTLV-1 PVL in males (833± 108) was lower compared with females (1218± 141 copies/104 PBMCs) (P=0. 05). Patients with HTLV-1-PVL of more than 500 copies/104 had more diffused atherosclerosis plaque than patients with less than 500 (OR=6. 87, 95% CI=1. 34-35. 05; P=0. 016). Furthermore, patients with diffused coronary atherosclerosis had significantly higher levels of HTLV-1 PVL than patients with middle, proximal, and normal location of coronary sclerotic lesions (P<0. 05). Conclusion: Taken together, in endemic area, HTLV-1 infection, more likely is a facilitating factor for heart complications and the high HTLV-1 PVL might affect CAD manifestations.

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APA: Copy

Mozayeni, Farnaz, REZAEE, SEYED ABDOLRAHIM, JABBARI AZAD, FARAHZAD, Shabestari, Mahmoud, Faridhosseini, Reza, RAFATPANAH, HOUSHANG, YOUSEFZADEH, HADIS, Garivani, Yousef Ali, JARAHI, LIDA, VALIZADEH, NARGES, Sabet, Faezah, Moshirahmadi, Sharare, Mohammadi, Fatemeh Sadat, & Shabestari, Mohammad. (2020). High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseas. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(4), 500-506. SID. https://sid.ir/paper/753785/en

Vancouver: Copy

Mozayeni Farnaz, REZAEE SEYED ABDOLRAHIM, JABBARI AZAD FARAHZAD, Shabestari Mahmoud, Faridhosseini Reza, RAFATPANAH HOUSHANG, YOUSEFZADEH HADIS, Garivani Yousef Ali, JARAHI LIDA, VALIZADEH NARGES, Sabet Faezah, Moshirahmadi Sharare, Mohammadi Fatemeh Sadat, Shabestari Mohammad. High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseas. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(4):500-506. Available from: https://sid.ir/paper/753785/en

IEEE: Copy

Farnaz Mozayeni, SEYED ABDOLRAHIM REZAEE, FARAHZAD JABBARI AZAD, Mahmoud Shabestari, Reza Faridhosseini, HOUSHANG RAFATPANAH, HADIS YOUSEFZADEH, Yousef Ali Garivani, LIDA JARAHI, NARGES VALIZADEH, Faezah Sabet, Sharare Moshirahmadi, Fatemeh Sadat Mohammadi, and Mohammad Shabestari, “High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseas,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 4, pp. 500–506, 2020, [Online]. Available: https://sid.ir/paper/753785/en

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