High-level Gentamicin Resistance and Detection of aac (6’ )Ie-aph (2” )Ia Gene in Enterococci Isolated from Pediatric Hospital in Northwest of Iran

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Choukhachian Mahsa; NAHAEI MOHAMMAD REZA; AHANGARZADEH REZAEE MOHAMMAD; SADEGHI JAVID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Archives of Clinical Infectious Diseases Year:2018 | Volume:13 | Issue:5 Page(s): 0-0

Download Full-Text

View:

169

Download:

Cites:

Information Journal Paper

Title

High-level Gentamicin Resistance and Detection of aac (6’ )Ie-aph (2” )Ia Gene in Enterococci Isolated from Pediatric Hospital in Northwest of Iran

Author(s)

Choukhachian Mahsa | NAHAEI MOHAMMAD REZA | AHANGARZADEH REZAEE MOHAMMAD | SADEGHI JAVID | Issue Writer Certificate

Keywords

Enterococcus

Gentamicin

Antibiotic Resistance

Iran

Abstract

Background: Enterococci form a part of the normal flora of the intestinal tract, the oral cavity, and the vagina; also, they can cause UTI, septicemia, intraabdominal abscesses, and nosocomial infections. High-level Gentamicin resistance (HLGR) in enterococci is mediated by aminoglycoside modifying enzymes, which is mainly encoded by aac (6’ )-Ie-aph (2” )-Ia gene. Objectives: The present study aimed at investigating high-level Gentamicin resistance in enterococci isolated from a pediatric hospital in Tabriz and detecting aac (6’ ) Ie-aph (2” ) Ia gene. Methods: In a descriptive and prospective study, a total of 100 enterococcal isolates were collected during September 2014 and June 2015 from a pediatric hospital in Tabriz, northwest of Iran. Bacterial identification and species determination were performed by standard biochemical tests. Antimicrobial susceptibility tests were performed by Kirby Bauer disc diffusion method. The frequency of aac (6’ )-Ie-aph (2” )-Ia gene in the isolates was determined by polymerase chain reaction. Results: Antibiotic susceptibility tests revealed that the highest resistance was against erythromycin (79%) and tetracycline (74%), whereas the highest susceptibility was observed against chloramphenicol (86%). Resistance to ampicillin, ciprofloxacin, and vancomycin were detected in 47%, 53%, and 42% of the isolates, respectively. In this study, 31 isolates (31%) were identified as HLGR from which 21 (67. 74%) had resistance gene of aac (6’ )-Ie-aph (2” )-Ia in their genome. The prevalence of resistance to other antibiotics and multi-drug resistance (MDR) was higher among the HLGR isolates compared to the non-HLGR isolates. Conclusions: High prevalence rates of MDR and HLGR enterococci are important problems associated with medical settings. The results of this study indicated that aac (6’ )-Ie-aph (2” )-Ia resistance gene is highly prevalent among Gentamicin resistant isolates.

Cites

No record.

References

No record.

Cite

APA: Copy

Choukhachian, Mahsa, NAHAEI, MOHAMMAD REZA, AHANGARZADEH REZAEE, MOHAMMAD, & SADEGHI, JAVID. (2018). High-level Gentamicin Resistance and Detection of aac (6’ )Ie-aph (2” )Ia Gene in Enterococci Isolated from Pediatric Hospital in Northwest of Iran. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 13(5), 0-0. SID. https://sid.ir/paper/753802/en

Vancouver: Copy

Choukhachian Mahsa, NAHAEI MOHAMMAD REZA, AHANGARZADEH REZAEE MOHAMMAD, SADEGHI JAVID. High-level Gentamicin Resistance and Detection of aac (6’ )Ie-aph (2” )Ia Gene in Enterococci Isolated from Pediatric Hospital in Northwest of Iran. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2018;13(5):0-0. Available from: https://sid.ir/paper/753802/en

IEEE: Copy

Mahsa Choukhachian, MOHAMMAD REZA NAHAEI, MOHAMMAD AHANGARZADEH REZAEE, and JAVID SADEGHI, “High-level Gentamicin Resistance and Detection of aac (6’ )Ie-aph (2” )Ia Gene in Enterococci Isolated from Pediatric Hospital in Northwest of Iran,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 13, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/753802/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops