Clinical Manifestations in Iranian Ataxia Telangiectasia Patients

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Moeini Shad Tannaz; Ranjouri Mohammad Reza; Amirifar Parisa

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Immunology and Genetics Journal Year:2020 | Volume:3 | Issue:1 Page(s): 30-39

Download Full-Text

View:

735

Download:

Cites:

Information Journal Paper

Title

Clinical Manifestations in Iranian Ataxia Telangiectasia Patients

Author(s)

Moeini Shad Tannaz | Ranjouri Mohammad Reza | Amirifar Parisa | Issue Writer Certificate

Keywords

ataxia telangiectasia

autosomal recessive

primary immunodeficiency disorders

ataxia telangiectasia mutated

Abstract

Background/objectives: AT is an autosomal recessive primary immunodeficiency (PID) disease with multisystem involvement caused by biallelic mutations in the ataxia telangiectasia mutated (ATM) gene. The patients with AT represent a broad range of clinical manifestations including progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, and susceptibility to malignancies. We aimed to determine different clinical features of the AT patients to identify their key diagnostic or prognostic characteristics. Methods: In the present study, 120 patients with the confirmed diagnosis of AT were enrolled from Iranian immunodeficiency registry center. A demographic information, clinical complications, and laboratory data were obtained from all the patients to evaluate the clinical manifestations. Results: In this study, we found that in the AT patients, the frequency of total infection, respiratory infection, gastrointestinal infection, urinary tract infection, chronic fever, lymphadenopathy, and hepatosplenomegaly were 83. 3%, 68. 3%, 18%, 6. 7%, 26. 7%, 7. 5%, and 20%, respectively. Conclusions: The AT patients present different types of infections and noninfectious complications; therefore, early detection and careful management is necessary for these patients.

Cites

No record.

References

Cite

APA: Copy

Moeini Shad, Tannaz, Ranjouri, Mohammad Reza, & Amirifar, Parisa. (2020). Clinical Manifestations in Iranian Ataxia Telangiectasia Patients. IMMUNOLOGY AND GENETICS JOURNA, 3(1), 30-39. SID. https://sid.ir/paper/754730/en

Vancouver: Copy

Moeini Shad Tannaz, Ranjouri Mohammad Reza, Amirifar Parisa. Clinical Manifestations in Iranian Ataxia Telangiectasia Patients. IMMUNOLOGY AND GENETICS JOURNA[Internet]. 2020;3(1):30-39. Available from: https://sid.ir/paper/754730/en

IEEE: Copy

Tannaz Moeini Shad, Mohammad Reza Ranjouri, and Parisa Amirifar, “Clinical Manifestations in Iranian Ataxia Telangiectasia Patients,” IMMUNOLOGY AND GENETICS JOURNA, vol. 3, no. 1, pp. 30–39, 2020, [Online]. Available: https://sid.ir/paper/754730/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops