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Information Journal Paper

Title

Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People

Pages

  107-114

Keywords

Nuclear factor-κB (NF-κB) 

Abstract

 Background: Aging is associated with attenuation of immune responses. Studies show that old people are vulnerable to infectious diseases such as influenza. α-Tocopherol as an immunomodulator affects immune responses. In the present study, the effect of α-Tocopherol, on Lymphocyte responses i. e. interferon-gamma (IFN-γ ), Tumor Necrosis Factor-alpha (TNF-α ), and nuclear factor-κ B (NF-κ B) in elderly individuals was evaluated. Materials and Methods: Heparinized blood samples were prepared from 10 elderly individuals (n=10, age >80 years) as the experimental group and 10 young individuals (n= 10, 20-40 years) as the control group. The separated Peripheral Blood Mononuclear Cells (PBMCs) of aged and young individuals were used for treatment with 2 μ g/mL of α-Tocopherol and 2 μ g/mL of Purified Protein Derivative (PPD) after 12 and 24 h incubation period. After isolation of total RNA and synthesize of cDNA, the gene expressions of IFN-γ , TNF-α , and NF-κ B were evaluated by real-time PCR method. β-Actin gene was considered as the internal control gene. Results: Results showed that treatment with α-Tocopherol increased the IFN-γ expression in old and young lymphocyte groups. The mRNA level of NF-κ B increased in the PPD group after 12 h in both old and young groups (P<0. 05). There were no alterations in TNF-α expression in both groups. Conclusion: It seems that α-Tocopherol is effective in the promotion of cytokine responses in old individuals and may be useful as a supplement for improving the immune system of elderly people.

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    Cite

    APA: Copy

    Darabi, Atifeh, HAGHIGHAT, SETAREH, & MAHDAVI, MEHDI. (2021). Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People. IMMUNOREGULATION, 3(2), 107-114. SID. https://sid.ir/paper/754787/en

    Vancouver: Copy

    Darabi Atifeh, HAGHIGHAT SETAREH, MAHDAVI MEHDI. Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People. IMMUNOREGULATION[Internet]. 2021;3(2):107-114. Available from: https://sid.ir/paper/754787/en

    IEEE: Copy

    Atifeh Darabi, SETAREH HAGHIGHAT, and MEHDI MAHDAVI, “Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People,” IMMUNOREGULATION, vol. 3, no. 2, pp. 107–114, 2021, [Online]. Available: https://sid.ir/paper/754787/en

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