Emerge of NDM-1-Producing Multidrug-Resistant Pseudomo-nas aeruginosa and Co-Harboring of Carbapenemase Genes in South of Iran

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FARAJZADEH SHEIKH AHMAD; SHAHIN MOJTABA; SHOKOOHIZADEH LEILI; GHANBARI FAHIMEH; Solgi Hamid; SHAHCHERAGHI FERESHTEH

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Journal: Iranian Journal of Public Health Year:2020 | Volume:49 | Issue:5 Page(s): 959-967

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Title

Emerge of NDM-1-Producing Multidrug-Resistant Pseudomo-nas aeruginosa and Co-Harboring of Carbapenemase Genes in South of Iran

Author(s)

Keywords

Pseudomonas aeruginosa

New Delhi metallo-β

-lactamase (blaNDM-1)

Modified hodge test (MHT)

Double-disk potentiation tests (DDPT)

Double disk synergy test (DDST)

Abstract

Background: New Delhi metallo-beta-lactamase-1 (NDM-1) is one of the most important emerging antibiotic resistance. Co-harboring three or four carbapenemases is rare and only a few reports exist in the literature. We described the characteristics of the large epidemic outbreaks and reports co-producing blaNDM-1 with the other carbapenemase genes in P. aeruginosa isolates. Methods: This present cross-sectional research was conducted on 369 P. aeruginosa isolates obtained from burn and general hospitals within years 2013 to 2016. Beta-lactamase classes A, B and D genes were identified by PCR method. Modified hodge test (MHT), double-disk potentiation tests (DDPT) and double disk synergy test (DDST) were performed for detection carbapenemase and metallo beta-lactamase (MBL) production of blaNDM-1 positive P. aeruginos isolates. Results: From 236 carbapenem-resistant P. aeruginosa (CRPA), 116 isolates have had MBL genes and twentynine isolates were found positive for blaNDM-1. In CRPA isolates, blaIMP-1, blaVIM-2 and blaOXA-10 were identified in 27. 5%, 21. 1% and 32. 2% of isolates respectively, while co-producing blaNDM-1, blaIMP-1, blaOXA-10, co-producing blaNDM-1, blaVIM-2, blaOXA-10 and co-producing blaIMP-1, blaVIM-2 were determined in 11 (4. 6%), 8 (3. 4%) and 27 (11. 4%) of isolates respectively. Conclusion: The finding of this co-existence of multiple carbapenemase resistance genes is threating for public health. Dipicolinic acid is a superior MBL inhibitor in DDPT antique than EDTA in DDST method for the detection of MBL-blaNDM-1 producing P. aeruginosa.

Cites

Incidence of Dominant Metallo-β-Lactamase Resistance Genes Produced in Pseudomonas aeruginosa Burn Infections in Iran: A Systemic Review and Meta-Analysis

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APA: Copy

FARAJZADEH SHEIKH, AHMAD, SHAHIN, MOJTABA, SHOKOOHIZADEH, LEILI, GHANBARI, FAHIMEH, Solgi, Hamid, & SHAHCHERAGHI, FERESHTEH. (2020). Emerge of NDM-1-Producing Multidrug-Resistant Pseudomo-nas aeruginosa and Co-Harboring of Carbapenemase Genes in South of Iran. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(5), 959-967. SID. https://sid.ir/paper/755775/en

Vancouver: Copy

FARAJZADEH SHEIKH AHMAD, SHAHIN MOJTABA, SHOKOOHIZADEH LEILI, GHANBARI FAHIMEH, Solgi Hamid, SHAHCHERAGHI FERESHTEH. Emerge of NDM-1-Producing Multidrug-Resistant Pseudomo-nas aeruginosa and Co-Harboring of Carbapenemase Genes in South of Iran. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(5):959-967. Available from: https://sid.ir/paper/755775/en

IEEE: Copy

AHMAD FARAJZADEH SHEIKH, MOJTABA SHAHIN, LEILI SHOKOOHIZADEH, FAHIMEH GHANBARI, Hamid Solgi, and FERESHTEH SHAHCHERAGHI, “Emerge of NDM-1-Producing Multidrug-Resistant Pseudomo-nas aeruginosa and Co-Harboring of Carbapenemase Genes in South of Iran,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. 5, pp. 959–967, 2020, [Online]. Available: https://sid.ir/paper/755775/en

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