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Information Journal Paper

Title

Frontier Therapeutics and Vaccine Strategies for SARS-CoV-2 (COVID-19): A Review

Pages

  18-29

Abstract

 COVID-19 is considered as the third human coronavirus and has a high potential for transmission. Fast public health interventions through antibodies, anti-virals or novel vaccine strategies to control the virus and disease transmission have been extremely followed. SARS-CoV-2 shares about 79% genomic similarity with SARSCoV and approximately 50% with MERS-CoV. Based on these similarities, prior knowledge in treating SARSCoV and MERS-CoV can be used as the basis of majority of the alternatives for controlling SARS-CoV-2. Immunotherapy is an effective strategy for clinical treatment of infectious diseases such as SARS-CoV-2. Passive antibody therapy, which decreases the virus replication and disease severity, is assessed as an effective therapeutic approach to control SARS-CoV-2 epidemics. The close similarity between SARS-CoV-2 genome with the SARS-CoV genome caused both coronaviruses to bind to the same angiotensin-converting enzyme 2 (ACE2) receptors that found in the human lung. There are several strategies to develop SARS-CoV-2 Vaccines, which the majority of them are based on those developed previously for SARS-CoV. The interaction between the spike (S) protein of SARS-CoV-2 and ACE2 on the host cell surface leads to the initiation of SARS-CoV-2 infection. S protein, which is the main inducer of neutralizing antibodies, has been targeted by most of these strategies. Vaccines that induce an immune response against the S protein to inhibit its binding with the host ACE2 receptor, can be considered as effective Vaccines against SARS-CoV-2. Here, we aimed to review frontier therapeutics and vaccination strategies for SARS-CoV-2 (COVID-19).

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    • Cite

    APA: Copy

    RANJBAR, REZA, SAEEDI, ELNAZ, SAFARPOOR DEHKORDI, FARHAD, HEIAT, MOHAMMAD, GHASEMI DEHKORDI, PAYAM, & GOODARZI, HAMED. (2020). Frontier Therapeutics and Vaccine Strategies for SARS-CoV-2 (COVID-19): A Review. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(SUPPLEMENT 1), 18-29. SID. https://sid.ir/paper/756783/en

    Vancouver: Copy

    RANJBAR REZA, SAEEDI ELNAZ, SAFARPOOR DEHKORDI FARHAD, HEIAT MOHAMMAD, GHASEMI DEHKORDI PAYAM, GOODARZI HAMED. Frontier Therapeutics and Vaccine Strategies for SARS-CoV-2 (COVID-19): A Review. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(SUPPLEMENT 1):18-29. Available from: https://sid.ir/paper/756783/en

    IEEE: Copy

    REZA RANJBAR, ELNAZ SAEEDI, FARHAD SAFARPOOR DEHKORDI, MOHAMMAD HEIAT, PAYAM GHASEMI DEHKORDI, and HAMED GOODARZI, “Frontier Therapeutics and Vaccine Strategies for SARS-CoV-2 (COVID-19): A Review,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. SUPPLEMENT 1, pp. 18–29, 2020, [Online]. Available: https://sid.ir/paper/756783/en

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