Oral Levetiracetam as Add-On Therapy in Refractory Neonatal Seizures

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MOLLAMOHAMMADI MOHSEN; AMIRHOSEINI Zeinab Sadat; SAADATI Alireza; PIRZADEH ZAHRA; HASSANVAND AMOUZADEH MASOUD

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Journal Paper

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Journal: Iranian Journal of Child Neurology Year:2018 | Volume:12 | Issue:4 Page(s): 103-110

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Title

Oral Levetiracetam as Add-On Therapy in Refractory Neonatal Seizures

Author(s)

Keywords

Neonatal seizure

Refractory Neonatal seizure

Oral levetiracetam

treatment

Abstract

Objective Seizure is the most common signs of nervous system disease in neonates. The first line of treatments in Neonatal seizures (after ruling out and emergency treatment of electrolyte imbalance and hypoglycemia) are phenobarbital and phenytoin. We aimed to evaluate drugs that are more effective on Neonatal seizure. Materials & Methods Patients admitted to neonatal wards & NICUs (level IIa&IIb) in Qom hospitals (2015-2017), central Iran with presentation of seizure, were enrolled in this clinical trial study. After ruling out electrolyte imbalance and hypoglycemia these neonates were managed by intravenous phenobarbital, then if no response was seen we added intravenous phenytoin and for remaining neonates with refractory seizure we applied Oral levetiracetam as add on therapy. The study was registered as code number of IRCT2016051527896N1. Results Initially, 245 neonates were enrolled. According to exclusion criteria, 12 cases were excluded, and phenobarbital was prescribed to the remaining patients. Out of these, 86 patients did not respond, and phenytoin was prescribed for them. Forty two patients who were not responding to phenytoin were finally treated with Oral levetiracetam. Finally, 95. 3% of seizures were controlled with Oral levetiracetam but 4. 7% were not cured. Conclusion: When the intravenous form of levetiracetam is not available and Neonatal seizure does not respond to first line classic drugs, Oral levetiracetam as add on therapy maybe effective.

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APA: Copy

MOLLAMOHAMMADI, MOHSEN, AMIRHOSEINI, Zeinab Sadat, SAADATI, Alireza, PIRZADEH, ZAHRA, & HASSANVAND AMOUZADEH, MASOUD. (2018). Oral Levetiracetam as Add-On Therapy in Refractory Neonatal Seizures. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 12(4), 103-110. SID. https://sid.ir/paper/757202/en

Vancouver: Copy

MOLLAMOHAMMADI MOHSEN, AMIRHOSEINI Zeinab Sadat, SAADATI Alireza, PIRZADEH ZAHRA, HASSANVAND AMOUZADEH MASOUD. Oral Levetiracetam as Add-On Therapy in Refractory Neonatal Seizures. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2018;12(4):103-110. Available from: https://sid.ir/paper/757202/en

IEEE: Copy

MOHSEN MOLLAMOHAMMADI, Zeinab Sadat AMIRHOSEINI, Alireza SAADATI, ZAHRA PIRZADEH, and MASOUD HASSANVAND AMOUZADEH, “Oral Levetiracetam as Add-On Therapy in Refractory Neonatal Seizures,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 12, no. 4, pp. 103–110, 2018, [Online]. Available: https://sid.ir/paper/757202/en

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