مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus (REVIEW ARTICLE)

Pages

  294-302

Abstract

 The pathogenesis of Systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors of gene regulation. In SLE, global and genespecific DNA methylation changes have been demonstrated to occur in CD4+ T-cells. Moreover, histone acetylation and deacetylation inhibitors reverse the expression of multiple genes involved in SLE, indicating histone modification in SLE. Autoreactive T-cells and B-cells have been shown to alter the patterns of epigenetic changes in SLE patients. Understanding the molecular mechanisms involved in the pathogenesis of SLE is critical for the introduction of effective, target-directed and tolerated therapies. In this review, we summarize the recent findings that highlight the importance of epigenetic modifications and their mechanisms in SLE.

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    APA: Copy

    FARIVAR, SHIRIN, & Shaabanpour Aghamaleki, Fateme. (2018). Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus (REVIEW ARTICLE). IRANIAN BIOMEDICAL JOURNAL, 22(5), 294-302. SID. https://sid.ir/paper/758255/en

    Vancouver: Copy

    FARIVAR SHIRIN, Shaabanpour Aghamaleki Fateme. Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus (REVIEW ARTICLE). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(5):294-302. Available from: https://sid.ir/paper/758255/en

    IEEE: Copy

    SHIRIN FARIVAR, and Fateme Shaabanpour Aghamaleki, “Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus (REVIEW ARTICLE),” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 5, pp. 294–302, 2018, [Online]. Available: https://sid.ir/paper/758255/en

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