Effect of Chronic Kidney Disease on Cardiovascular Events, An Epidemiological Aspect from SPRINT Trial

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ATTAR ARMIN; SAYADI MEHRAB

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2019 | Volume:13 | Issue:5 Page(s): 328-336

Download Full-Text

View:

146

Download:

180

Cites:

Information Journal Paper

Title

Effect of Chronic Kidney Disease on Cardiovascular Events, An Epidemiological Aspect from SPRINT Trial

Author(s)

ATTAR ARMIN | SAYADI MEHRAB | Issue Writer Certificate

Keywords

blood pressure

cardiovascular disease

chronic kidney disease

hypertension

Risk equivalent

SPRINT

Abstract

Introduction. Currently, conflicting evidence exists among community-based studies as to whether chronic kidney disease (CKD) is a cardiovascular (CVD) Risk equivalent. We aimed to evaluate the effect of CKD on CVD based on a large trial results. Methods. To perform a secondary analysis, we obtained the data of SPRINT trial from NHLBI data repository center. 2646 subjects with baseline CKD and 6715 without CKD were enrolled. A composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes was considered as primary outcome. Results. Throughout the 3. 21 years of follow-up, presence of CKD, compared to those without CKD, negatively affected the primary outcome (incidence rate, 2. 84% per year vs. 1. 55% per year in patients with and without CKD, respectively; Hazard ratio, 1. 83; 95% CI, 1. 49 to 2. 11; P <. 001). This finding was consistent across all the secondary outcomes. However, the risk was not as great as those with clinical cardiovascular disease (incidence rate, 4. 13% per year). Presence of CKD was the strongest predictor of developing AKI with intensive blood pressure reduction, increasing its chance by 215%. Conclusion. SPRINT is the first trial revealing that CKD is an independent risk factor for CVD. However, CKD could not be considered as a CVD Risk equivalent. In the presence of CKD, with intensive blood pressure reduction the chance of AKI is dramatically increased. IJKD

Cites

Comparison of Generalized Weibull and Weibull Parametric Models in Survival Analysis of Patients with Hypertension to Acute Renal Failure: Death due to Cardiovascular Disease as a Competing Risk

References

No record.

Cite

APA: Copy

ATTAR, ARMIN, & SAYADI, MEHRAB. (2019). Effect of Chronic Kidney Disease on Cardiovascular Events, An Epidemiological Aspect from SPRINT Trial. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 13(5), 328-336. SID. https://sid.ir/paper/759056/en

Vancouver: Copy

ATTAR ARMIN, SAYADI MEHRAB. Effect of Chronic Kidney Disease on Cardiovascular Events, An Epidemiological Aspect from SPRINT Trial. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2019;13(5):328-336. Available from: https://sid.ir/paper/759056/en

IEEE: Copy

ARMIN ATTAR, and MEHRAB SAYADI, “Effect of Chronic Kidney Disease on Cardiovascular Events, An Epidemiological Aspect from SPRINT Trial,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 13, no. 5, pp. 328–336, 2019, [Online]. Available: https://sid.ir/paper/759056/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops