CURCUMIN PROTECTS MICE TESTICULAR TISSUE AGAINST THE ADVERSE EFFECTS OF SODIUM ARSENITE: A STEREOLOGICAL STUDY

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SOLEIMANI MEHRANJANI MALEK; HATAMIKIA NAJMEH; Naderi Noreini Samira

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Journal: Journal of Kerman University of Medical Sciences Year:2016 | Volume:23 | Issue:6 Page(s): 714-726

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Title

CURCUMIN PROTECTS MICE TESTICULAR TISSUE AGAINST THE ADVERSE EFFECTS OF SODIUM ARSENITE: A STEREOLOGICAL STUDY

Author(s)

SOLEIMANI MEHRANJANI MALEK | HATAMIKIA NAJMEH | Naderi Noreini Samira | Issue Writer Certificate

Keywords

CURCUMINQ3

MICEQ2

SODIUM ARSENATEQ1

STEREOLOGYQ2

TESTISQ2

Abstract

Background & Aims: Sodium arsenite, an environmental pollutant, produces free radicals with harmful effects on the reproductive system. The aim of this study was to investigate the effect of CURCUMIN, as a strong antioxidant, on the TESTIS tissue and spermatogenic cell population in MICE treated with sodium arsenite.Methods: In this experimental study, Adult male NMRI MICE were randomly divided into the 5 groups (n=6): control, sodium arsenite (5mg/kg/day), CURCUMIN (15mg/kg/day), sodium arsenite+CURCUMIN and DMSO as vehicle. After 5 weeks of treatment (through intraperitoneal ingection), animals right TESTIS were removed, fixed, sectioned, stained (using heiden hain azan method) and stereologically studied. Data were analyzed using one-way ANOVA and Tuckey's test and the means were considered significantly different at p<0.05.Result: A significant decrease in the mean volume (P<0.05) and diameter (P<0.001) of seminiferous tubules, height of the germinal epithelium (P<0.01), thickness of the basement membrane (P<0.001) and the number of spermatocytes and spermatids (p<0.001) and a significant increase in the mean volume of the interstitial tissue was observed in the sodium arsenite group compared to the control ones (p<0.05). The above parameters were significantly compensated to the control level in the sodium arsenite+CURCUMIN group.Conclusions: CURCUMIN can compensate the harmful effects of sodium arsenite on the testicular tissue and spermatogenic cell populations in adult MICE. Therefore, it is suggested as a supplement in the case of arsenite intoxication.

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APA: Copy

SOLEIMANI MEHRANJANI, MALEK, HATAMIKIA, NAJMEH, & Naderi Noreini, Samira. (2016). CURCUMIN PROTECTS MICE TESTICULAR TISSUE AGAINST THE ADVERSE EFFECTS OF SODIUM ARSENITE: A STEREOLOGICAL STUDY. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 23(6), 714-726. SID. https://sid.ir/paper/76/en

Vancouver: Copy

SOLEIMANI MEHRANJANI MALEK, HATAMIKIA NAJMEH, Naderi Noreini Samira. CURCUMIN PROTECTS MICE TESTICULAR TISSUE AGAINST THE ADVERSE EFFECTS OF SODIUM ARSENITE: A STEREOLOGICAL STUDY. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(6):714-726. Available from: https://sid.ir/paper/76/en

IEEE: Copy

MALEK SOLEIMANI MEHRANJANI, NAJMEH HATAMIKIA, and Samira Naderi Noreini, “CURCUMIN PROTECTS MICE TESTICULAR TISSUE AGAINST THE ADVERSE EFFECTS OF SODIUM ARSENITE: A STEREOLOGICAL STUDY,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 6, pp. 714–726, 2016, [Online]. Available: https://sid.ir/paper/76/en

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