Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study

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FATHI MAROUFI NAZILA; Aghayi Elnaz; Garshasbi Hamid; Gholampour Matin Milad; Babazadeh Bedoustani Ahmad; Firouzi Amoudizaj Fatemeh; Hajazimian Saba; Isazadeh Alireza; TAEFEHSHOKR SINA; Taefehshokr Nima; BARADARAN BEHZAD

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:6 Page(s): 671-678

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Title

Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study

Author(s)

Keywords

Breast cancer

Interleukin 18

Polymorphism

Abstract

Breast cancer (BC) is the most frequently diagnosed cancer among women in the world. Genetic Polymorphisms in Interleukin (IL) genes are one of the most important risk factors in BC. The aim of this study was to investigate the association of rs1946518 C/A Polymorphism in the promoter region of the IL-18 gene and BC risk in Iranian women. In this case-control study, we recruited 140 women with BC as a case group and 140 age and ethnically matched women as healthy controls from East Azerbaijan, Tabriz in Iran. The genomic DNA was extracted using a salting-out method from peripheral blood leukocytes. Genotyping was performed using polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP). The genotype distribution in BC patients was 37. 86% CC, 47. 14% CA, and 15. 00% AA, whereas in healthy controls these were 40. 72% CC, 42. 85% CA, and 16. 43% AA. Statistical analysis showed that the genotype and allele frequencies of IL-18 rs1946518 C/A Polymorphism were not significantly different between BC patients and healthy controls (p>0. 05). The only significant difference between cases and controls was related to family history (p=0. 023). In conclusion, our study indicated that IL-18 rs1946518 C/A Polymorphism was not associated with BC in the Iranian women population. However, more studies on different races and geographic areas are required to determine the exact role of rs1946518 C/A Polymorphism in prognosis, diagnosis, and risk of BC.

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Inhibition of Cervical Cancer Cell Line Hela by Human Wharton’ s Jelly Stem Cells Through Induction of Apoptosis

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APA: Copy

FATHI MAROUFI, NAZILA, Aghayi, Elnaz, Garshasbi, Hamid, Gholampour Matin, Milad, Babazadeh Bedoustani, Ahmad, Firouzi Amoudizaj, Fatemeh, Hajazimian, Saba, Isazadeh, Alireza, TAEFEHSHOKR, SINA, Taefehshokr, Nima, & BARADARAN, BEHZAD. (2019). Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(6), 671-678. SID. https://sid.ir/paper/761619/en

Vancouver: Copy

FATHI MAROUFI NAZILA, Aghayi Elnaz, Garshasbi Hamid, Gholampour Matin Milad, Babazadeh Bedoustani Ahmad, Firouzi Amoudizaj Fatemeh, Hajazimian Saba, Isazadeh Alireza, TAEFEHSHOKR SINA, Taefehshokr Nima, BARADARAN BEHZAD. Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(6):671-678. Available from: https://sid.ir/paper/761619/en

IEEE: Copy

NAZILA FATHI MAROUFI, Elnaz Aghayi, Hamid Garshasbi, Milad Gholampour Matin, Ahmad Babazadeh Bedoustani, Fatemeh Firouzi Amoudizaj, Saba Hajazimian, Alireza Isazadeh, SINA TAEFEHSHOKR, Nima Taefehshokr, and BEHZAD BARADARAN, “Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 6, pp. 671–678, 2019, [Online]. Available: https://sid.ir/paper/761619/en

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