SELENIUM AND GLUTATHIONE PEROXIDASE DEFICIENCY IN EPILEPTIC CHILDREN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAMS S.; ASHRAFI M.R.; NOURI MEHRNAZ; IRANI HESHMAT; HAGHI ASHTIANI M.T.; MOHSENI AMENEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pediatrics Year:2007 | Volume:17 | Issue:2 (SUPPLEMENT) Page(s): 173-178

Download Full-Text

Persian Verion

View:

1,854

Download:

Cites:

Information Journal Paper

Title

SELENIUM AND GLUTATHIONE PEROXIDASE DEFICIENCY IN EPILEPTIC CHILDREN

Author(s)

Keywords

SELENIUMQ2

GLUTATHIONE PEROXIDASEQ2

SEIZUREQ3

EPILEPSYQ3

OXIDATIVE STRESSQ3

FREE RADICALSQ3

Abstract

Objective: To cease the increasing damage to the brain neurons following epileptic SEIZUREs, natural anti-oxidative systems play the main role. One of the most important detoxifying systems is composed of the trace element SELENIUM and its dependent detoxifying enzyme, GLUTATHIONE PEROXIDASE. The object of this study was to evaluate serum SELENIUM and red blood cell GLUTATHIONE PEROXIDASE activity in pediatric epileptics and compare it with that of healthy children. Material & Methods: Patients suffering from various types of EPILEPSY were studied during a 15-month period. Control group consisted of healthy children with no history of any neurologic disease. Serum SELENIUM level and RBC GLUTATHIONE PEROXIDASE activity was evaluated and the results compared. Findings: Fifty three epileptic patients with a mean age of 5.5 years and 57 healthy children with a mean age of 5.6 years were enrolled in this study. Statistically significant differences in the mean values for serum SELENIUM level (72.9 vs. 86.0 ng/ml, P=0.017) and also RBC GLUTATHIONE PEROXIDASE activity (440.6 vs. 801.0 nmol/min/ml, P=0.000) between the two groups were observed. On the other hand, after analyzing the study results, trying to introduce a value for GPx activity, which could be accepted as a reliable indicator for serum SELENIUM deficiency in patients, was not successful.Conclusion: Findings of the present study strongly support the proposed crucial role for the trace element SELENIUM and deficiency of its dependent enzyme, GLUTATHIONE PEROXIDASE, in EPILEPSY pathogenesis.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAMS, S., ASHRAFI, M.R., NOURI, MEHRNAZ, IRANI, HESHMAT, HAGHI ASHTIANI, M.T., & MOHSENI, AMENEH. (2007). SELENIUM AND GLUTATHIONE PEROXIDASE DEFICIENCY IN EPILEPTIC CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 17(2 (SUPPLEMENT)), 173-178. SID. https://sid.ir/paper/76166/en

Vancouver: Copy

SHAMS S., ASHRAFI M.R., NOURI MEHRNAZ, IRANI HESHMAT, HAGHI ASHTIANI M.T., MOHSENI AMENEH. SELENIUM AND GLUTATHIONE PEROXIDASE DEFICIENCY IN EPILEPTIC CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2007;17(2 (SUPPLEMENT)):173-178. Available from: https://sid.ir/paper/76166/en

IEEE: Copy

S. SHAMS, M.R. ASHRAFI, MEHRNAZ NOURI, HESHMAT IRANI, M.T. HAGHI ASHTIANI, and AMENEH MOHSENI, “SELENIUM AND GLUTATHIONE PEROXIDASE DEFICIENCY IN EPILEPTIC CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 17, no. 2 (SUPPLEMENT), pp. 173–178, 2007, [Online]. Available: https://sid.ir/paper/76166/en

Related Journal Papers