Does exercise training attenuate cisplatin nephrotoxicity?

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Kafashi Mina; KAFFASHIAN MOHAMMAD REZA; NEMATBAKHSH MEHDI; MALEKI MARYAM; SAFARI TAHEREH

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Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2020 | Volume:9 | Issue:4 Page(s): 0-0

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Title

Does exercise training attenuate cisplatin nephrotoxicity?

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Keywords

Aerobic training

Acute kidney injury

Nephrotoxicity

Cisplatin

Abstract

Cisplatin (CP), a medication originating from the platinum has been used for solid cancers’ treatment in the last decade. CP is associated with numerous side effects as well. One of the side effects is Nephrotoxicity. There are some types of procedure which can attenuate harmful effects of the drug, and the effectiveness of physical activity has been a controversial topic. It is well established that physical activity has positive effects on chronic kidney disease (CKD). The exercise training can modulate CP induced muscle wasting both in males and females. Although exercise training may have protective effect on renal function and the related risk factors, it cannot attenuate the renal injury resulted from CP therapy in females. The exercise training may improve interleukin 6 and heme oxygenase-1, reduces the production of CD4+T cell cytokines from the kidney, which play a major role in adaptive immune response. The present mini-review considered the effect of exercise training accompanied by the CP treatment.

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APA: Copy

Kafashi, Mina, KAFFASHIAN, MOHAMMAD REZA, NEMATBAKHSH, MEHDI, MALEKI, MARYAM, & SAFARI, TAHEREH. (2020). Does exercise training attenuate cisplatin nephrotoxicity?. JOURNAL OF RENAL INJURY PREVENTION, 9(4), 0-0. SID. https://sid.ir/paper/761910/en

Vancouver: Copy

Kafashi Mina, KAFFASHIAN MOHAMMAD REZA, NEMATBAKHSH MEHDI, MALEKI MARYAM, SAFARI TAHEREH. Does exercise training attenuate cisplatin nephrotoxicity?. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2020;9(4):0-0. Available from: https://sid.ir/paper/761910/en

IEEE: Copy

Mina Kafashi, MOHAMMAD REZA KAFFASHIAN, MEHDI NEMATBAKHSH, MARYAM MALEKI, and TAHEREH SAFARI, “Does exercise training attenuate cisplatin nephrotoxicity?,” JOURNAL OF RENAL INJURY PREVENTION, vol. 9, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/761910/en

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