Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds: A meta-analysis study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DAVOODI ALI; KHOSHVISHKAIE ELNAZ; AZADBAKHT MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pharmaceutical and Biomedical Research Year:2019 | Volume:5 | Issue:2 Page(s): 1-9

Download Full-Text

View:

194

Download:

Cites:

Information Journal Paper

Title

Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds: A meta-analysis study

Author(s)

DAVOODI ALI | KHOSHVISHKAIE ELNAZ | AZADBAKHT MOHAMMAD | Issue Writer Certificate

Keywords

Plant cell

hairy root

callus

immobilized cell

meta-analysis

Abstract

Natural-based drugs are the important bioactive substances that have been used for prevention and treatment of diseases. Natural products are prepared in commercial scale from relevant medicinal plants. Hence, large amounts of the plants are needed for extraction and isolation of naturally occurring compounds. Plant cells technology is the best strategy for the production of the plant-derived drugs, which have difficulty process in large scale production. This study was conducted for types, frequencies and efficacies of production methods for natural-based drugs in Plant cell technology as an alternative method to preparation from whole herb. Pharmaceutical and biomedical databases including PubMed/Medline, Scopus, Web of Science, Embase, ProQuest and Google Scholar were searched in this study. Moreover, keywords words were ''secondary metabolite production'', ''pharmaceutical natural compounds'', ''high scale production'', ''cell suspension'', ''immobilized Plant cell'', “ hairy root” , ''elicitor'', ''substrate'', ''Plant cell'', ''callus'', ''medicinal plants'', ''isolation and purification''. The correlations have been investigated by random effect model in an Excel program. Findings of this meta-analysis study showed all production methods had high efficacies and percentages of high scale production from 90 to 100%, which were comparable with conventional direct extractions. In addition to, median efficacy values for cell suspension, callus, hairy root and immobilized Plant cell methods in production of selected drugs (atropine, paclitaxel, vincristine, camptothecin and colchicine) with 1124, 257, 797 and 969 events were 92. 49 (CI95%: 89. 78-95. 86), 91. 98 (CI95%: 89. 13-95. 25), 95. 69 (CI95%: 92. 84-98. 68) and 93. 86% (CI95%: 91. 12-96. 35), respectively. The Plant cell technology for production of secondary metabolites has various advantages including high accuracy, repeatability and productivity, that is a best strategy for production of natural-based drugs.

Cites

Optimization of Ultrasound-Assisted Acidic-Solvent Extraction of Colchicine from Colchicum kurdicum (Bornm. ) Stef. Using Response Surface Methodology

References

Cite

APA: Copy

DAVOODI, ALI, KHOSHVISHKAIE, ELNAZ, & AZADBAKHT, MOHAMMAD. (2019). Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds: A meta-analysis study. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 5(2), 1-9. SID. https://sid.ir/paper/763732/en

Vancouver: Copy

DAVOODI ALI, KHOSHVISHKAIE ELNAZ, AZADBAKHT MOHAMMAD. Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds: A meta-analysis study. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2019;5(2):1-9. Available from: https://sid.ir/paper/763732/en

IEEE: Copy

ALI DAVOODI, ELNAZ KHOSHVISHKAIE, and MOHAMMAD AZADBAKHT, “Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds: A meta-analysis study,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 5, no. 2, pp. 1–9, 2019, [Online]. Available: https://sid.ir/paper/763732/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops