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Information Journal Paper

Title

Protective impact of Rosa damascena against neural damage in a rat model of pentylenetetrazole (PTZ)-induced seizure

Pages

  574-583

Abstract

 Objective: Based on the previously-declared anticonvulsant properties of Rosa damascena (R. damascena), this study explored the probable effects of R. damascena on neuronal apoptosis in the hippocampus of a rat model of pentylenetetrazole (PTZ)-induced seizure. Materials and Methods: 40 male Wistar rats were randomely divided into control (n=8) and experimental (n=32) groups which underwent PTZ injection. A one-week pre-medication with 50 (PTZ-Ext 50) (n=8), 100 (PTZ-Ext 100) (n=8), and 200 (PTZ-Ext 200) (n=8) mg/kg of hydro-alcoholic extract of R. Damascene was performed while one experimental group (PTZ-induced group) (n=8) received only saline during the week before PTZ injection. After provocation of PTZ-induced seizures, the brains underwent tissue processing and TUNEL staining assay for apoptotic cell quantification. Results: Our findings revealed that PTZ-induced seizures led to apoptosis in neuronal cells of all sub-regions of the hippocampus; yet, only at CA1, CA3 and DG sub-regions of the PTZ-induced group, the difference in the number of apoptotic neuronal cells was significant in comparison with the control group. In addition, pre-medication with the plant extract led to a significant drop in the quantity of apoptotic neurons in these sub-regions in comparison with the PTZ-induced group which received no pre-medication. Conclusion: The results of this study showed that R. damascena extract exerts neuro-protective effects on PTZ-induced seizure.

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    Cite

    APA: Copy

    HOMAYOUN, MANSOUR, Shafieian, Reyhaneh, SEGHATOLESLAM, MASOUMEH, HOSSEINI, MAHMOUD, & EBRAHIMZADEH BIDESKAN, ALIREZA. (2020). Protective impact of Rosa damascena against neural damage in a rat model of pentylenetetrazole (PTZ)-induced seizure. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(6), 574-583. SID. https://sid.ir/paper/764890/en

    Vancouver: Copy

    HOMAYOUN MANSOUR, Shafieian Reyhaneh, SEGHATOLESLAM MASOUMEH, HOSSEINI MAHMOUD, EBRAHIMZADEH BIDESKAN ALIREZA. Protective impact of Rosa damascena against neural damage in a rat model of pentylenetetrazole (PTZ)-induced seizure. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(6):574-583. Available from: https://sid.ir/paper/764890/en

    IEEE: Copy

    MANSOUR HOMAYOUN, Reyhaneh Shafieian, MASOUMEH SEGHATOLESLAM, MAHMOUD HOSSEINI, and ALIREZA EBRAHIMZADEH BIDESKAN, “Protective impact of Rosa damascena against neural damage in a rat model of pentylenetetrazole (PTZ)-induced seizure,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 6, pp. 574–583, 2020, [Online]. Available: https://sid.ir/paper/764890/en

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