مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,171
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

DETECTION OF BETA-THALASSEMIA MUTATIONS IN KURD PATIENTS OF KURDISTAN AND WEST AZERBAIJAN PROVINCES

Pages

  51-58

Abstract

 Background and Aim: b-thalassemia is the most common autosomal recessive disorder. More than 200 different MUTATIONs in the b-globin gene have been detected which can lead to decreased or absent b-globin chain synthesis. Since the Iranian population is a mixture of different ethnic groups, it is necessary to determine the frequency and distribution of these MUTATIONs in the different ethnic groups of our country. Therefore, in this study we determined the spectrum and the frequency of thalassemia MUTATIONs in the patients with b-thalassemia major in the KURD population of KURDistan and West Azerbaijan provinces of Iran.Material and Methods: To detect MUTATIONs, extracted DNA of 110 chromosomes from 55 unrelated patients, were_ studied by PCR-ARMS (Polymerase Chain Reaction-Amplification Refractory MUTATION System), SSCP (Single Strand Conformation Polymorphism) and direct sequencing methods.Results: The results of this study showed that IVS-II-1 (G®A) was the most common MUTATION with a frequency of 31%; FSC*8/9(+G) with a frequency of 19% was the second most prevalent MUTATION among all chromosomes. Other MUTATIONs were IVS-I-1(G®A), FSC8 (-AA), IVS-I-110(G®A), FSC36/37(-T), IVS-I- 5(G®C), IVS-I-128(T®G), FSC44 (-C), FSC 5(-CT) and +22UTR* (G®A). These MUTATIONs comprised 79% of b-thalassemia MUTATIONs in this region and 21% of the MUTATIONs still remains to be explored.Conclusion: The results of this study showed that, there are similarities and differences between this region and other parts of Iran and also neighboring countries. Therefore, determination of b-thalassemia MUTATIONs in this region seems to be necessary and beneficial for designing prenatal diagnosis programs.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    KHOURSHIDI, SH., HAGHI, MAHDI, HOSSEINPOUR FEYZI, M.A., AMIN BAKHSH, M., HOSSEINPOUR FEYZI, A.A., & POULADI, N.. (2008). DETECTION OF BETA-THALASSEMIA MUTATIONS IN KURD PATIENTS OF KURDISTAN AND WEST AZERBAIJAN PROVINCES. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 13(1 (SERIAL NUMBER 47)), 51-58. SID. https://sid.ir/paper/76547/en

    Vancouver: Copy

    KHOURSHIDI SH., HAGHI MAHDI, HOSSEINPOUR FEYZI M.A., AMIN BAKHSH M., HOSSEINPOUR FEYZI A.A., POULADI N.. DETECTION OF BETA-THALASSEMIA MUTATIONS IN KURD PATIENTS OF KURDISTAN AND WEST AZERBAIJAN PROVINCES. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;13(1 (SERIAL NUMBER 47)):51-58. Available from: https://sid.ir/paper/76547/en

    IEEE: Copy

    SH. KHOURSHIDI, MAHDI HAGHI, M.A. HOSSEINPOUR FEYZI, M. AMIN BAKHSH, A.A. HOSSEINPOUR FEYZI, and N. POULADI, “DETECTION OF BETA-THALASSEMIA MUTATIONS IN KURD PATIENTS OF KURDISTAN AND WEST AZERBAIJAN PROVINCES,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 1 (SERIAL NUMBER 47), pp. 51–58, 2008, [Online]. Available: https://sid.ir/paper/76547/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top