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Information Journal Paper

Title

Bone Repair via Osteon and Bio-Oss: A Comparative Histological and Histomorphometric Animal Study

Pages

  26-33

Abstract

 Background and Aim: Autogenous bone grafts are considered the gold standard although they have several disadvantages, leading to a search for suitable alternative graft biomaterials. This study evaluates the histological and histomorphometric properties of regenerated bone in defects in rabbits following the application of two commercially available xenografts (Bio-Oss and Osteon). Materials and Methods: This animal study was carried out on 14 New Zealand rabbit calvaria. Four 6. 5-mm critical-size defect (CSD) models of bone regeneration were formed in each surgical site. The first defect was filled with Bio-Oss, the second with large Osteon (L-Osteon), the third with small Osteon (S-Osteon), and the last one remained unfilled (the control group). The cases were sacrificed. Bone forming properties (amount of new Bone Formation, inflammation, and foreign body reaction) were observed at 4-and 8-week intervals through histological and histomorphometric examinations. The Friedman test, Kruskal-Wallis test, and Wilcoxon test for multiple comparisons were used for data analysis. The level of statistical significance was set at 0. 05. Result: There was no statistically significant difference for regenerated bone among the four groups (P>0. 05). The L-Osteon site showed more inflammation and foreign body reaction compared to the other groups. Conclusion: The results of this study showed that Bio-Oss and Osteon appear to be highly biocompatible and osteoconductive and can thus successfully be used as Bone Substitutes in augmentation procedures.

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    APA: Copy

    SARKARAT, F., Vahdati, S.A., Mahaseni aghdam, h.r., NEMATALLAHI, Z., & FARAHMAND, M.. (2020). Bone Repair via Osteon and Bio-Oss: A Comparative Histological and Histomorphometric Animal Study. JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES, 5(2), 26-33. SID. https://sid.ir/paper/765577/en

    Vancouver: Copy

    SARKARAT F., Vahdati S.A., Mahaseni aghdam h.r., NEMATALLAHI Z., FARAHMAND M.. Bone Repair via Osteon and Bio-Oss: A Comparative Histological and Histomorphometric Animal Study. JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES[Internet]. 2020;5(2):26-33. Available from: https://sid.ir/paper/765577/en

    IEEE: Copy

    F. SARKARAT, S.A. Vahdati, h.r. Mahaseni aghdam, Z. NEMATALLAHI, and M. FARAHMAND, “Bone Repair via Osteon and Bio-Oss: A Comparative Histological and Histomorphometric Animal Study,” JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES, vol. 5, no. 2, pp. 26–33, 2020, [Online]. Available: https://sid.ir/paper/765577/en

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