مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

112
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

112
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation

Pages

  102-108

Abstract

 Objective(s): L-4-borono-2-18F-fluoro-phenylalanine (L-[18F]FBPA), a substrate of Ltype amino acid transporter 1 (LAT1), is a tumor-specific probe used in positron emission tomography (PET). On the other hand, it has not been examined whether another isomer D-[18F]FBPA accumulates specifically in the tumor. Here, we compared the accumulation of D-[18F]FBPA in C6 glioma and inflammation to evaluate the performance of D-[18F]FBPA as a tumor-specific probe. Methods: HEK293-LAT1 and HEK293-LAT2 cells were tested for [14C]-leucine or [14C]-alanine transport, and IC50 values of L-and D-FBPA were evaluated in both cell types. PET was conducted in rat xenograft model of C6 glioma with LAT1 expression and model of turpentine oil-induced subcutaneous inflammation (n=10 for both models). The concentrations of D-[18F]FBPA were compared between glioma and inflammatory lesion using standardized uptake value (SUV). Results: In contrast to L-FBPA, which inhibited substrate uptake in both HEK293-LAT1 and-LAT2 cells, D-FBPA showed no inhibitory effect on both cells, suggesting low transporter selectivity of D-[18F]FBPA against LAT1 and LAT2. Static PET analysis showed low accumulation of D-[18F]FBPA in C6 glioma and inflammatory lesion (SUVmax=0. 80± 0. 16, 0. 56± 0. 09, respectively). Although there was a statistical difference in SUVmax between these tissues, it was difficult to distinguish glioma from inflammation on the PET image due to its low uptake level. Therefore, it was suggested that D-[18F]FBPA is not a suitable tumor-specific probe for oncology PET in contrast to L-[18F]FBPA. Conclusion: This study demonstrated that D-[18F]FBPA is not a LAT1-specific PET probe and shows low uptake in C6 glioma, indicating its unsuitability as a tumor diagnosis PET probe.

Cites

  • No record.
  • References

    Cite

    APA: Copy

    Hirai, Nobuto, WATABE, TADASHI, Nagamori, Shushi, Wiriyasermkul, Pattama, Tanaka, Yoko, Romanov, Victor, NAKA, SADAHIRO, KANAI, YASUKAZU, Liu, Yuwei, Tani, Naoki, Sakai, Tatsuya, TATSUMI, MITSUAKI, & Kanai, Yoshikatsu. (2020). Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 8(2), 102-108. SID. https://sid.ir/paper/765800/en

    Vancouver: Copy

    Hirai Nobuto, WATABE TADASHI, Nagamori Shushi, Wiriyasermkul Pattama, Tanaka Yoko, Romanov Victor, NAKA SADAHIRO, KANAI YASUKAZU, Liu Yuwei, Tani Naoki, Sakai Tatsuya, TATSUMI MITSUAKI, Kanai Yoshikatsu. Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2020;8(2):102-108. Available from: https://sid.ir/paper/765800/en

    IEEE: Copy

    Nobuto Hirai, TADASHI WATABE, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Victor Romanov, SADAHIRO NAKA, YASUKAZU KANAI, Yuwei Liu, Naoki Tani, Tatsuya Sakai, MITSUAKI TATSUMI, and Yoshikatsu Kanai, “Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 8, no. 2, pp. 102–108, 2020, [Online]. Available: https://sid.ir/paper/765800/en

    Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button