BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY ON PREVENTIVE EFFECTS OF PUNICA GRANATUM L. EXTRACT ON FATTY LIVER DISEASE IN THE RATS RECEIVING HIGH FAT DIET

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AMIRI H.; FAKOUR SH.; AKRADI L.

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2018 | Volume:23 | Issue:3 (95) Page(s): 45-55

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Title

BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY ON PREVENTIVE EFFECTS OF PUNICA GRANATUM L. EXTRACT ON FATTY LIVER DISEASE IN THE RATS RECEIVING HIGH FAT DIET

Author(s)

AMIRI H. | FAKOUR SH. | AKRADI L. | Issue Writer Certificate

Keywords

PUNICA EXTRACTQ2

FATTY LIVERQ2

HEPATIC ENZYMEQ2

ANTIOXIDANTQ2

BIOCHEMICAL STUDIESQ2

Abstract

Background and Aim: Non-alcoholic FATTY LIVER disease (NAFLD) is recognized as a metabolic liver disease in the world. The purpose of this study was to investigate the preventive effects of Punica granatum extract on FATTY LIVER disease in the rats receiving high fat diet.Material and Methods: In this study rats were divided into 6 groups: healthy control, feeding with high fat diet, feeding with high fat diet plus clofibrate and feeding with high fat diet plus Punica granatum extract with different doses for 6 weeks. At the end of the experiment biochemical indices including LDL, HDL, triglyceride and cholesterol, HEPATIC ENZYMEs (AST, ALT, ALP) and concentrations of GPX, SOD, and CAT ANTIOXIDANTs in serum were measured. After histopathologic examinations and grading of FATTY LIVER the groups were compared with one another.Results: High-fat diet group showed statistically significant increase in HEPATIC ENZYMEs, cholesterol, triglyceride and LDL compared to other groups. Whereas high dose extract and clofibrate groups showed statistically significant increase in HDL and ANTIOXIDANT activity compared to other groups. The results of histopathological examination showed FATTY LIVER changes of grade 4 in the high-fat diet, grade 1 in the extract and grade zero in the clofibrate groups.Conclusion: The results of this study showed the preventive effect of Kurdistan native Punica on FATTY LIVER disease which is related to its ANTIOXIDANT properties.

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APA: Copy

AMIRI, H., FAKOUR, SH., & AKRADI, L.. (2018). BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY ON PREVENTIVE EFFECTS OF PUNICA GRANATUM L. EXTRACT ON FATTY LIVER DISEASE IN THE RATS RECEIVING HIGH FAT DIET. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(3 (95) ), 45-55. SID. https://sid.ir/paper/76614/en

Vancouver: Copy

AMIRI H., FAKOUR SH., AKRADI L.. BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY ON PREVENTIVE EFFECTS OF PUNICA GRANATUM L. EXTRACT ON FATTY LIVER DISEASE IN THE RATS RECEIVING HIGH FAT DIET. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(3 (95) ):45-55. Available from: https://sid.ir/paper/76614/en

IEEE: Copy

H. AMIRI, SH. FAKOUR, and L. AKRADI, “BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY ON PREVENTIVE EFFECTS OF PUNICA GRANATUM L. EXTRACT ON FATTY LIVER DISEASE IN THE RATS RECEIVING HIGH FAT DIET,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 3 (95) , pp. 45–55, 2018, [Online]. Available: https://sid.ir/paper/76614/en

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