THE EFFECT OF SODIUM NITROPRUSSIDE ON TRACHEAL SMOOTH MUSCLE OF RABBIT

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HEJAZIAN SH.; DASHTI M.H.; ABBASI SARCHESHMEH ABOU ALGHASEM; HALVANI GH.H.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:10 | Issue:1 (Serial number 35) Page(s): 1-8

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Title

THE EFFECT OF SODIUM NITROPRUSSIDE ON TRACHEAL SMOOTH MUSCLE OF RABBIT

Author(s)

HEJAZIAN SH. | DASHTI M.H. | ABBASI SARCHESHMEH ABOU ALGHASEM | HALVANI GH.H. | Issue Writer Certificate

Keywords

SNPQ4

SMOOTH MUSCLEQ2

ITPQ3

Abstract

Background and Aim: excitation and contraction of the SMOOTH MUSCLEs in the airways lead to the constriction which causes abnormal airflow. Nitric oxide is considered as one of the most important factors which cause SMOOTH MUSCLEs relaxation. Since Sodium Nitroprusside (S.N.P) is used in emergency services as a potent NO donor and many reports have indicated that this agent causes the SMOOTH MUSCLEs relaxation, so this study was designed to determine the effect of S.N.P on tracheal SMOOTH MUSCLE of rabbit. Materials and Methods: in this study intratracheal pressure (I.T.P) was recorded as an index of contraction of tracheal SMOOTH MUSCLE. Control groups were exposed to the electrical stimulation with various voltages and frequencies. Treatment groups were first exposed to various concentrations of S.N.P along with the same electrical stimulation as the control groups. Results: Our results showed that in the treatment groups, different concentrations of S.N.P significantly increased ITP (p<0.05). When they were exposed to various concentrations of S.N.P along with electrical stimulation, the lowest concentration of S.N.P (0.5×10-6 M), decreased the ITP in response to electrical stimulation with different voltages and frequencies (p=0.00). Application of medium and high concentrations of S.N.P led to the increase of ITP in response to electrical stimulation. ITP was significantly increased following administration of the medium concentration of S.N.P. (1.66×10-7M) SNP (p=0.00). SNP, 5×10-8M, also led to a significant increase of ITP in all voltages and frequencies (p<0.05). Conclusion: According to our findings, S.N.P had an excitatory concentration-dependant effect on the tracheal SMOOTH MUSCLE and only the minimum concentrations induced relaxation of the muscles.

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APA: Copy

HEJAZIAN, SH., DASHTI, M.H., ABBASI SARCHESHMEH, ABOU ALGHASEM, & HALVANI, GH.H.. (2005). THE EFFECT OF SODIUM NITROPRUSSIDE ON TRACHEAL SMOOTH MUSCLE OF RABBIT. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 10(1 (Serial number 35)), 1-8. SID. https://sid.ir/paper/76656/en

Vancouver: Copy

HEJAZIAN SH., DASHTI M.H., ABBASI SARCHESHMEH ABOU ALGHASEM, HALVANI GH.H.. THE EFFECT OF SODIUM NITROPRUSSIDE ON TRACHEAL SMOOTH MUSCLE OF RABBIT. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;10(1 (Serial number 35)):1-8. Available from: https://sid.ir/paper/76656/en

IEEE: Copy

SH. HEJAZIAN, M.H. DASHTI, ABOU ALGHASEM ABBASI SARCHESHMEH, and GH.H. HALVANI, “THE EFFECT OF SODIUM NITROPRUSSIDE ON TRACHEAL SMOOTH MUSCLE OF RABBIT,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 1 (Serial number 35), pp. 1–8, 2005, [Online]. Available: https://sid.ir/paper/76656/en

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