COMPARISON OF THE ANTI OXIDANT ENZYME (GPX) AND (GR) ACTIVITIES IN THE BLOOD OF THE WOMEN SUFFERING FROM BREAST CANCER WITH HEALTHY FEMALES IN IMAM KHOMEINI HOSPITAL IN TEHRAN IN 1382

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JALALI M.; NEGAHDAR M.

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Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:10 | Issue:1 (Serial number 35) Page(s): 15-22

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Title

COMPARISON OF THE ANTI OXIDANT ENZYME (GPX) AND (GR) ACTIVITIES IN THE BLOOD OF THE WOMEN SUFFERING FROM BREAST CANCER WITH HEALTHY FEMALES IN IMAM KHOMEINI HOSPITAL IN TEHRAN IN 1382

Author(s)

JALALI M. | NEGAHDAR M. | Issue Writer Certificate

Keywords

ANTIOXIDANTS ENZYMEQ4

GRQ4

GPXQ2

BREAST CANCERQ1

ROSQ2

Abstract

Background and Aim: There is much evidence implicating environmental factors such as diet regimens containing high animal proteins, alcohol consumption, chemical carcinogens … etc. to be among the risk factors of BREAST CANCER and are involved in the production of reactive oxygen species. Reactive oxygen species can per oxidize, lipids, reduce enzyme activities and damage DNA, hence the play an important role in the pathogenesis of cancers.Materials and Methods: We investigated Glutathione peroxides (GPX) and Glutathione reductase activities in the whole blood samples taken from 2 age-matched GRoups, 50 healthy women and 50 patients suffering from BREAST CANCER (BC).Results: The rate of GPX and GR activities in BC patients were significantly lower (p<0.001) than those of control GRoup. We found an age related reduction in the activity of GPX and GR enzymes (p<0.05).Conclusion: The results of our study have shown a gig her Reactive oxygen species (ROS) production and decreased GPX and GR activities, which lend support to the oxidative stress hypothesis in carcinogenesis. GPX and GR enzymes with diminished activities may not be adequate to detoxify high levels of H2O2 into H2O, and dangerous 0OH radicals are produced. Therefore, administration of antioxidants may be helpful in the management of BC patients. However, further elaborate clinical studies are required to evaluate the role of such antioxidant enzymes in BC management.

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APA: Copy

JALALI, M., & NEGAHDAR, M.. (2005). COMPARISON OF THE ANTI OXIDANT ENZYME (GPX) AND (GR) ACTIVITIES IN THE BLOOD OF THE WOMEN SUFFERING FROM BREAST CANCER WITH HEALTHY FEMALES IN IMAM KHOMEINI HOSPITAL IN TEHRAN IN 1382. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 10(1 (Serial number 35)), 15-22. SID. https://sid.ir/paper/76661/en

Vancouver: Copy

JALALI M., NEGAHDAR M.. COMPARISON OF THE ANTI OXIDANT ENZYME (GPX) AND (GR) ACTIVITIES IN THE BLOOD OF THE WOMEN SUFFERING FROM BREAST CANCER WITH HEALTHY FEMALES IN IMAM KHOMEINI HOSPITAL IN TEHRAN IN 1382. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;10(1 (Serial number 35)):15-22. Available from: https://sid.ir/paper/76661/en

IEEE: Copy

M. JALALI, and M. NEGAHDAR, “COMPARISON OF THE ANTI OXIDANT ENZYME (GPX) AND (GR) ACTIVITIES IN THE BLOOD OF THE WOMEN SUFFERING FROM BREAST CANCER WITH HEALTHY FEMALES IN IMAM KHOMEINI HOSPITAL IN TEHRAN IN 1382,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 1 (Serial number 35), pp. 15–22, 2005, [Online]. Available: https://sid.ir/paper/76661/en

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