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Information Journal Paper

Title

Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain

Pages

  205-212

Abstract

 Background: Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through the inhibition of cyclooxygenases. Objectives: This study evaluated the effect of NSAIDs in inducing antinociception either alone or in combination in mice formalin Orofacial pain. Methods: Male mice were injected intraperitoneally with dexibuprofen, dexketoprofen, diclofenac meloxicam, metamizole and piroxicam. Then from a dose-response curve the ED50 (dose that produce 50% of maximum effect) was obtained from each drug. Results: The administration of NSAIDs produced a dose-dependent antinociception in both phases of the assay with different potency. Then, combinations of the cited NSAIDs were tested and analyzed by Isobolographic analysis. The results demonstrate that the nocifensive response induced when dexketoprofen (DEX), the dextrorotatory enantiomer of the S (+) configuration of ketoprofen, was combined with piroxicam, diclofenac, dexibuprofen, metamizole, and meloxicam, was synergistic, either in Phase I or Phase II of the formalin orofacial mice assay. Conclusion: The data demonstrated that the NSAIDs administered alone or in combination produce antinociception. These effects need to be explained by other mechanisms of action of NSAIDs other than the simple inhibition of COXs. The findings may be relevant for the relief of acute or chronic pain such as migraine, post‐ herpetic neuralgia and tooth pain.

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    Cite

    APA: Copy

    Noriega, Viviana, Sierralta, Fernando, Aranda, Nicolas, Sotomayor Zarate, Ramon, Poblete, Paula, Prieto, Juan Carlos, & Miranda, Hugo F.. (2020). Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(3), 205-212. SID. https://sid.ir/paper/768124/en

    Vancouver: Copy

    Noriega Viviana, Sierralta Fernando, Aranda Nicolas, Sotomayor Zarate Ramon, Poblete Paula, Prieto Juan Carlos, Miranda Hugo F.. Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(3):205-212. Available from: https://sid.ir/paper/768124/en

    IEEE: Copy

    Viviana Noriega, Fernando Sierralta, Nicolas Aranda, Ramon Sotomayor Zarate, Paula Poblete, Juan Carlos Prieto, and Hugo F. Miranda, “Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 3, pp. 205–212, 2020, [Online]. Available: https://sid.ir/paper/768124/en

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