Au nanoparticles/g-C3N4 modified electrochemical biosensor for detection of gastric cancer miRNA based on hairpin locked nucleic acids probe

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMAD SHAFIEE MOHAMMAD REZA; Parhizkar Janan

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2020 | Volume:5 | Issue:2 Page(s): 152-159

Download Full-Text

View:

134

Download:

Cites:

Information Journal Paper

Title

Au nanoparticles/g-C3N4 modified electrochemical biosensor for detection of gastric cancer miRNA based on hairpin locked nucleic acids probe

Author(s)

MOHAMMAD SHAFIEE MOHAMMAD REZA | Parhizkar Janan | Issue Writer Certificate

Keywords

Au/ g

C3N4 composite biosensors Gastric cancer miRNA

106a square wave voltammetry

Abstract

Objective(s): The annual incidence of cancer in the world is growing rapidly. The most important factor in the cure of cancers is their early diagnosis. miRNA, as a biomarker for detection of cancer in early stage, has attracted a lot of attention. Methods: In this research, an electrochemical biosensor was designed to detect the amount of miR-106a, the biomarker of gastric cancer, by modifying a glassy carbon electrode (GCE) with a composite of g-C3N4 and Au nanoparticles. Complementary DNA strand of miR-106a which modified with biotin was used as a probe. Nanoparticles of titanium phosphate modified with Streptavidin and zinc ions were used to generate the electrochemical signal in square wave voltammetry. To identify the g-C3N4 functional group, the chemical composition of the titanium phosphate nanoparticles, the morphology and elemental composition of composite Fourier transform Infrared Spectroscopy, X-Ray Diffraction, Field Emission Scanning Electron Microscopy, and Energy Dispersive X-Ray Spectroscopy were used, respectively. Results: The peaks of C, N, and Au in EDS spectrum confirmed composite formation. The linear range of the modified biosensor for miRNA-106a was obtained from 0.6 to 6.4 nM. The detection limit was calculated 80 pM. Conclusions: Ultimately, Au nanoparticles/ g-C3N4 composite modified electrode can be a good platform for making electrochemical biosensor to diagnosis cancer in early stages.

Cites

No record.

References

Cite

APA: Copy

MOHAMMAD SHAFIEE, MOHAMMAD REZA, & Parhizkar, Janan. (2020). Au nanoparticles/g-C3N4 modified electrochemical biosensor for detection of gastric cancer miRNA based on hairpin locked nucleic acids probe. NANOMEDICINE RESEARCH JOURNAL, 5(2), 152-159. SID. https://sid.ir/paper/774457/en

Vancouver: Copy

MOHAMMAD SHAFIEE MOHAMMAD REZA, Parhizkar Janan. Au nanoparticles/g-C3N4 modified electrochemical biosensor for detection of gastric cancer miRNA based on hairpin locked nucleic acids probe. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2020;5(2):152-159. Available from: https://sid.ir/paper/774457/en

IEEE: Copy

MOHAMMAD REZA MOHAMMAD SHAFIEE, and Janan Parhizkar, “Au nanoparticles/g-C3N4 modified electrochemical biosensor for detection of gastric cancer miRNA based on hairpin locked nucleic acids probe,” NANOMEDICINE RESEARCH JOURNAL, vol. 5, no. 2, pp. 152–159, 2020, [Online]. Available: https://sid.ir/paper/774457/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops