Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer

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Hashemzadeh Kamelia; Jokar Mohammad Hassan; SEDIGHI SIMA; Moradzadeh Maliheh

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Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2019 | Volume:11 | Issue:1 Page(s): 5-16

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Information Journal Paper

Title

Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer

Author(s)

Hashemzadeh Kamelia | Jokar Mohammad Hassan | SEDIGHI SIMA | Moradzadeh Maliheh | Issue Writer Certificate

Keywords

Gastrointestinal cancer

PI3K pharmacological inhibitors

Clinical trials

Abstract

Therapeutic targeting of phosphatidyl-inositol 3-kinase (PI3K) is considered as a possible strategy in several types of cancer, including gastrointestinal ones. In vitro and in vivo studies indicated the significance of proapoptotic and antiproliferative inhibition of PI3K. Although there are many phase 1 and 2 Clinical trials on PI3K inhibitors in patients with Gastrointestinal cancer, the molecular mechanism of PI3K targeting PI3K/ mTOR pathway is not clear. Panclass I, isoformselective, and dual PI3K/mTOR inhibitors are under investigation. This review aimed to indicate PI3K-dependent targeting mechanisms in Gastrointestinal cancer and the evaluation of related clinical data.

Cites

Hamartomatous Polyposis Syndromes: Management and Surveillance Strategies

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APA: Copy

Hashemzadeh, Kamelia, Jokar, Mohammad Hassan, SEDIGHI, SIMA, & Moradzadeh, Maliheh. (2019). Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 11(1), 5-16. SID. https://sid.ir/paper/775443/en

Vancouver: Copy

Hashemzadeh Kamelia, Jokar Mohammad Hassan, SEDIGHI SIMA, Moradzadeh Maliheh. Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2019;11(1):5-16. Available from: https://sid.ir/paper/775443/en

IEEE: Copy

Kamelia Hashemzadeh, Mohammad Hassan Jokar, SIMA SEDIGHI, and Maliheh Moradzadeh, “Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 11, no. 1, pp. 5–16, 2019, [Online]. Available: https://sid.ir/paper/775443/en

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