SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST

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NARIMAN N.; KHATAMSAZ S.; SHARIFI E.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:4 (99) Page(s): 346-356

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Title

SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST

Author(s)

NARIMAN N. | KHATAMSAZ S. | SHARIFI E. | Issue Writer Certificate

Keywords

SENSORY THRESHOLDS OF PAINQ2

PAIN SCOREQ2

METABOLIC ALKALOSISQ2

RATQ2

Abstract

Background & aim: METABOLIC ALKALOSIS is one of the most common disorders of the acid-base body fluids which follows many of the metabolic and non-metabolic diseases in the body, and as a strong affective factor after establishment, it can influence the performance of other organs. The aim of this study was to examine the possible changes in the sensory threshold of pain in offsprings born to mothers with METABOLIC ALKALOSIS in comparison with those born to healthy mothers.Methods: In the present experimental study, fifty mature female Westar RATs, weighing 180±20gr, were randomly divided into five groups: the control left untreated, the sham received calcium carbonate solution for thirty days before and through pregnancy. The experimental group was divided into three alkalosis groups of minimum, medium and maximum doses. Sodium bicarbonate was dissolved in drinking water to produce alkalosis in the experimental groups. The groups with minimum, medium and maximum alkalosis received 0.2M Sodium bicarbonate for 10, 20 and 30 days respectively before and during pregnancy. Following the birth of offspring, the treatment was stopped, and water used to the end of the experiment. Offsprings were kept to adulthood, and then males and females were separated. The study of sensory threshold of pain was conducted on male offsprings by formalin test procedure. PAIN SCOREs were recorded in acute and chronic stages, and were compared among different groups. The qathered data was statistically analyzed by SPSS software, and Tukey and Anova test.Results: The results indicated a significant increase in the PAIN SCOREs during acute (0-5min) and chronic stages (16-60min) of formalin test in male RAT offspring born to mothers with METABOLIC ALKALOSIS compared to control and sham groups (P£0.05).Conclusion: Alkalosis with such effects can reduce sensory threshold of pain in children born to mothers with METABOLIC ALKALOSIS and increase the pain. Consequently, by preventing METABOLIC ALKALOSIS in pregnant women, we can reduce sensory threshold pain in children.

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APA: Copy

NARIMAN, N., KHATAMSAZ, S., & SHARIFI, E.. (2015). SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST. ARMAGHAN DANESH, 20(4 (99)), 346-356. SID. https://sid.ir/paper/77580/en

Vancouver: Copy

NARIMAN N., KHATAMSAZ S., SHARIFI E.. SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST. ARMAGHAN DANESH[Internet]. 2015;20(4 (99)):346-356. Available from: https://sid.ir/paper/77580/en

IEEE: Copy

N. NARIMAN, S. KHATAMSAZ, and E. SHARIFI, “SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST,” ARMAGHAN DANESH, vol. 20, no. 4 (99), pp. 346–356, 2015, [Online]. Available: https://sid.ir/paper/77580/en

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