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Information Journal Paper

Title

Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting

Pages

  28-34

Abstract

 Background and objectives: Cardiovascular disease is one of the most important causes of mortality worldwide. The present study aimed to compare two different cardiac rehabilitation protocols on ATP-binding cassette sub-family G member 1 (ABCG1) lymphocyte expression and blood lipid profile in middle-aged men undergoing Coronary Artery Bypass grafting. Methods: Forty five middle-aged men who had previously undergone Coronary Artery Bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last Exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests. Results: Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups. Conclusion: Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis.

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    Cite

    APA: Copy

    Moosavi, Rokhsareh, RASHID LAMIR, AMIR, Khajeie, Rambod, & Hejazi, Mahmoud. (2021). Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting. MEDICAL LABORATORY JOURNAL, 15(2), 28-34. SID. https://sid.ir/paper/775867/en

    Vancouver: Copy

    Moosavi Rokhsareh, RASHID LAMIR AMIR, Khajeie Rambod, Hejazi Mahmoud. Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting. MEDICAL LABORATORY JOURNAL[Internet]. 2021;15(2):28-34. Available from: https://sid.ir/paper/775867/en

    IEEE: Copy

    Rokhsareh Moosavi, AMIR RASHID LAMIR, Rambod Khajeie, and Mahmoud Hejazi, “Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting,” MEDICAL LABORATORY JOURNAL, vol. 15, no. 2, pp. 28–34, 2021, [Online]. Available: https://sid.ir/paper/775867/en

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