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Information Journal Paper

Title

Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced Diabetic Rats

Pages

  34-40

Abstract

 Background and objectives: It has been suggested that Irisin and fibronectin type III domain-containing protein 5 (FNDC5) can increase energy expenditure, promote weight loss and improve insulin resistance in diabetic patients by affecting white and brown adipose tissues. In this study, we investigate effect of Adipose tissue-derived stem cell transplantation and six weeks of Aerobic exercise on FNDC5 and Irisin levels in streptozotocin-induced diabetic rats. Methods: Forty-eight rats (weighing 220-240 g and aged nine weeks) were divided into six groups of control, sham, Diabetes control, Diabetes + exercise, Diabetes + stem cell and Diabetes+ exercise + stem cell. The exercise group ran on running wheel at intensity of 60-70% VO2max, five days a week for six weeks. Next, 1. 56 × 106 stem cells extracted from human adipose tissue were injected into the tail vein of streptozotocin-induced diabetic rats. Finally, FNDC5 and Irisin plasma levels of the mice were measured using enzymelinked immunosorbent assay kits. Results: FNDC5 and Irisin levels reduced significantly in the Diabetes control group (P=0. 0001). FNDC5 levels in the Diabetes + exercise + stem cell and the exercise group increased significantly compared to the Diabetes control group (P=0. 0001). The Irisin level in the Diabetes + stem cell + exercise group, exercise group and stem cell group increased significantly compared to the Diabetes control group (P=0. 0001). Conclusion: The results indicate that Aerobic exercise program and stem cell therapy alone and combined can significantly increase plasma Irisin levels. Given the favorable effects of Adipose tissue-derived stem cell injection and Aerobic exercise on FNDC5 and Irisin levels, this strategy could be further evaluated in coping with the adverse effects of Diabetes on metabolism and aging.

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    APA: Copy

    Nasiraei, Mehdi, JAFARI CHASHMI, ABDOLREZA, & Hashemvarzi, Seyd Abdollah. (2020). Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced Diabetic Rats. MEDICAL LABORATORY JOURNAL, 14(6), 34-40. SID. https://sid.ir/paper/775944/en

    Vancouver: Copy

    Nasiraei Mehdi, JAFARI CHASHMI ABDOLREZA, Hashemvarzi Seyd Abdollah. Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced Diabetic Rats. MEDICAL LABORATORY JOURNAL[Internet]. 2020;14(6):34-40. Available from: https://sid.ir/paper/775944/en

    IEEE: Copy

    Mehdi Nasiraei, ABDOLREZA JAFARI CHASHMI, and Seyd Abdollah Hashemvarzi, “Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced Diabetic Rats,” MEDICAL LABORATORY JOURNAL, vol. 14, no. 6, pp. 34–40, 2020, [Online]. Available: https://sid.ir/paper/775944/en

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