In Vitro Evaluation of Antibacterial and Antifungal Properties of Some New 1, 3, 4-Oxadiazole Derivatives Containing Phenyl Group

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZARRABI AHRABI NAKISA; SOULDOZI ALI; Sarve Ahrabi Yasin

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Infection Epidemiology and Microbiology Year:2020 | Volume:6 | Issue:3 Page(s): 177-192

Download Full-Text

View:

201

Download:

Cites:

Information Journal Paper

Title

In Vitro Evaluation of Antibacterial and Antifungal Properties of Some New 1, 3, 4-Oxadiazole Derivatives Containing Phenyl Group

Author(s)

ZARRABI AHRABI NAKISA | SOULDOZI ALI | Sarve Ahrabi Yasin | Issue Writer Certificate

Keywords

Oxadiazole

Enterococcus faecalis

Drug resistance

Abstract

Aims: Antibiotic resistance is recognized as one of the most challenging public health problems in the world. The need for new antibacterial and antifungal drugs is justified because many pathogens are currently resistant to available drugs. Several components of 1, 3, 4‑ Oxadiazoles have been shown to pose a wide range of antibacterial activities. Materials & Methods: The new derivatives of 1, 3, 4-Oxadiazole were synthesized using a single-stage method. The structure of derivatives was evaluated by IR, H-NMR, C-NMR, and GC-Mass methods. Then to measure the antibacterial and antifungal activities of the prepared derivatives at a concentration of 0. 5 mg/mL, agar well diffusion method was employed, and the minimum inhibitory concentration (MIC) and the minimum bactericidal/fungicidal concentration (MBC/MFC) were determined with three replications. Findings: The study of antibacterial properties of the prepared derivatives showed the highest activity of the compounds 4b-g against Enterococcus faecalis strains, among which the compound 4g with IZ= 55. 66 ± 0. 5 mm and MIC=31. 25 mg/mL had the greatest effect compared to the others. Also, the compound 4f with MIC= 125 mg/mL had a powerful effect against E. faecalis strains. In the case of fungal samples, the highest activity of the compound 4b was with IZ=12. 33± 0. 5 mm against Candida glabrata and with IZ=13. 33± 0. 5 mm against C. krusei strains. Conclusion: The new 1, 3, 4‑ Oxadiazole derivatives (4b, 4d, and 4g) with tolyl, dimetylphenyl, and methoxyphenyl groups were shown to be a promising compounds for pharmaceutical applications so that by adding other functional groups to their structure, it is possible to increase the destructive power of these compounds.

Cites

In Vitro Evaluation of Antimicrobial Properties of Some Newly Synthesized S-Triazole Thioglycosides

References

Cite

APA: Copy

ZARRABI AHRABI, NAKISA, SOULDOZI, ALI, & Sarve Ahrabi, Yasin. (2020). In Vitro Evaluation of Antibacterial and Antifungal Properties of Some New 1, 3, 4-Oxadiazole Derivatives Containing Phenyl Group. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 6(3), 177-192. SID. https://sid.ir/paper/776977/en

Vancouver: Copy

ZARRABI AHRABI NAKISA, SOULDOZI ALI, Sarve Ahrabi Yasin. In Vitro Evaluation of Antibacterial and Antifungal Properties of Some New 1, 3, 4-Oxadiazole Derivatives Containing Phenyl Group. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2020;6(3):177-192. Available from: https://sid.ir/paper/776977/en

IEEE: Copy

NAKISA ZARRABI AHRABI, ALI SOULDOZI, and Yasin Sarve Ahrabi, “In Vitro Evaluation of Antibacterial and Antifungal Properties of Some New 1, 3, 4-Oxadiazole Derivatives Containing Phenyl Group,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 6, no. 3, pp. 177–192, 2020, [Online]. Available: https://sid.ir/paper/776977/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops