Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

178
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

85
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats

Pages

  33-39

Abstract

 Background and objectives: Cardiac apoptosis is one of the most important cardiovascular complications of diabetes. We aimed to investigate the changes of Bax, Bcl2 and caspase 3 in cardiac tissue of diabetic rats after six weeks aerobic exercise. Methods: Thirty two male Wistar rats were randomly divided into healthy control, diabetes control and diabetes + exercise groups. diabetes was induced by intraperitoneal injection of streptozotocin solution (55 mg/kg). Two weeks after the injection, fasting blood glucose levels were measured to confirm induction of diabetes. The exercise program was performed five days a week for six weeks. Variables were evaluated by ELISA and western blot analysis. All statistical analyses were performed in SPSS (version 22) using ANOVA and at significance of 0. 05. Results: The induction of diabetes in the control groups resulted in a significant increase in Bax, Bax/Bcl2 ratio and a significant decrease in Bcl2 levels (P=0. 024). The six-week training exercise in diabetic groups significantly decreased Bax and Bax/Bcl2 ratio and significantly increased Bcl2 (P=0. 018). Conclusion: Our finding showed that diabetes could increase apoptosis in cardiac tissue. In addition, the six-week aerobic exercise can be used as a non-pharmacological strategy to reduce diabetes-related apoptosis in cardiomyocytes.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Sadighi, Aghil, ABDI, AHMAD, AZARBAYJANI, MOHAMMAD ALI, & BARARI, ALIREZA. (2021). Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats. MEDICAL LABORATORY JOURNAL, 15(1), 33-39. SID. https://sid.ir/paper/777238/en

    Vancouver: Copy

    Sadighi Aghil, ABDI AHMAD, AZARBAYJANI MOHAMMAD ALI, BARARI ALIREZA. Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats. MEDICAL LABORATORY JOURNAL[Internet]. 2021;15(1):33-39. Available from: https://sid.ir/paper/777238/en

    IEEE: Copy

    Aghil Sadighi, AHMAD ABDI, MOHAMMAD ALI AZARBAYJANI, and ALIREZA BARARI, “Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats,” MEDICAL LABORATORY JOURNAL, vol. 15, no. 1, pp. 33–39, 2021, [Online]. Available: https://sid.ir/paper/777238/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top