ASSOCIATION STUDY OF POLYMORPHISM IN CYP3A5 GENE WITH BLADDER CANCER IN TEHRAN

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BAKHTIARI TAJAR M.; ONSORY KH.; SHADPOOR P.; ZAFARMAND M.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:6 (101) Page(s): 494-504

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Title

ASSOCIATION STUDY OF POLYMORPHISM IN CYP3A5 GENE WITH BLADDER CANCER IN TEHRAN

Author(s)

BAKHTIARI TAJAR M. | ONSORY KH. | SHADPOOR P. | ZAFARMAND M. | Issue Writer Certificate

Keywords

CYP3A5 GENEQ2

POLYMORPHISMQ2

BLADDER CANCERQ3

PCR-RFLPQ2

Abstract

Background & aim: The CYP3A enzyme catalyzes the conversion of numerous numbers of xenobiotics and materials including carcinogens and drugs. The CYP3A5 is expressed polymorphically in human liver, but consistently in lung, colon, and kidney. The purpose of this study was to analysis the frequency of A®G transition mutation in CYP3A5 GENE and to determine the role of this POLYMORPHISM in BLADDER CANCER patients admitted to clinic center between 1991-1992 years.Methods: In the present study, PCR-RFLP analysis of the gene was conducted on 113 BLADDER CANCER patients and same number of age-matched controls admitted to Hashemi Nezhad Hospital. After amplifying the gene, digestion was performed using specific restriction enzyme and then fragments were investigated using agarose gel. Subsequently, the data was analyzed by the SPSS (version 19) using logistic regression.Results: The incidence of CYP3A5*3 allele was more in patients and control group compared with the wild type (CYP3A5*1). It was 79.6% and 75.2% in patients and controls respectively which indicated that the mutant allele of CYP3A5*3 was more in the studied population with an OR of 1.837 (95% CI=0.975-3.460, P=0.62). Also there was found that the frequency of both alleles were high in female compared with male. No association was found between genotypes with grade and stage of cancer in patients.Conclusions: No significant association was observed between the risks of BLADDER CANCER for individuals carrying the mutant allele of CYP3A5 GENE.

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APA: Copy

BAKHTIARI TAJAR, M., ONSORY, KH., SHADPOOR, P., & ZAFARMAND, M.. (2015). ASSOCIATION STUDY OF POLYMORPHISM IN CYP3A5 GENE WITH BLADDER CANCER IN TEHRAN. ARMAGHAN DANESH, 20(6 (101)), 494-504. SID. https://sid.ir/paper/77821/en

Vancouver: Copy

BAKHTIARI TAJAR M., ONSORY KH., SHADPOOR P., ZAFARMAND M.. ASSOCIATION STUDY OF POLYMORPHISM IN CYP3A5 GENE WITH BLADDER CANCER IN TEHRAN. ARMAGHAN DANESH[Internet]. 2015;20(6 (101)):494-504. Available from: https://sid.ir/paper/77821/en

IEEE: Copy

M. BAKHTIARI TAJAR, KH. ONSORY, P. SHADPOOR, and M. ZAFARMAND, “ASSOCIATION STUDY OF POLYMORPHISM IN CYP3A5 GENE WITH BLADDER CANCER IN TEHRAN,” ARMAGHAN DANESH, vol. 20, no. 6 (101), pp. 494–504, 2015, [Online]. Available: https://sid.ir/paper/77821/en

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