EVALUATION OF MEXILETINE EFFECT ON DURATION OF SENSORY AND MOTOR BLOCK IN SPINAL ANESTHESIA WITH LIDOCAINE

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HAGHBIN M.; ASKARZADEH M.; SHARIFZADEH M.; SHABANI M.

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Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:2 (85) Page(s): 100-110

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Title

EVALUATION OF MEXILETINE EFFECT ON DURATION OF SENSORY AND MOTOR BLOCK IN SPINAL ANESTHESIA WITH LIDOCAINE

Author(s)

HAGHBIN M. | ASKARZADEH M. | SHARIFZADEH M. | SHABANI M. | Issue Writer Certificate

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Abstract

Background & aim: Considering the fact that there are several methods are considered for addition time of spinal anesthesia. The aim of this study was to evaluate the effect of premedication on time mexiletine sensory and motor block in spinal anesthesia with lidocaine.Methods: In this clinical trial, 60 patients undergoing lower extremity surgery aged 15-50 years according to the American Society of Anesthesiology class I and II, which were referred to the Shahid Bahonar Hospital, were randomly assigned to the intervention and control two equal groups.The intervention group was received 200 mg mexiletine capsules two hours before the operation and the control group was given placebo. Spinal anesthesia was carried out in both groups with a 5% lidocaine solution (100 mg) in the L3-L4 or L2-L3 with the same approach. Mean arterial pressure, heart rate, arterial oxygen saturation was recorded at intervalsof 5- 10 minutes.The data were analyzed using the paired t-test statistic.Results: Onset of sensory and motor block was significantly shorter than intervention group (p<0.01). Duration of sensory and motor block of intervention group was significantly higher than control group (p<0.01). Rate in the intervention group at time 0, 5, 10, 60 and 75 min after administration of spinal anesthesia was less than the control group (p<0.05).Conclusion: Mexiletine is effective in increasing duration of sensory and motor block in spinal anesthesia. It also increases the speed of onset of spinal anesthesia with lidocaine.

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APA: Copy

HAGHBIN, M., ASKARZADEH, M., SHARIFZADEH, M., & SHABANI, M.. (2014). EVALUATION OF MEXILETINE EFFECT ON DURATION OF SENSORY AND MOTOR BLOCK IN SPINAL ANESTHESIA WITH LIDOCAINE. ARMAGHAN DANESH, 19(2 (85)), 100-110. SID. https://sid.ir/paper/78004/en

Vancouver: Copy

HAGHBIN M., ASKARZADEH M., SHARIFZADEH M., SHABANI M.. EVALUATION OF MEXILETINE EFFECT ON DURATION OF SENSORY AND MOTOR BLOCK IN SPINAL ANESTHESIA WITH LIDOCAINE. ARMAGHAN DANESH[Internet]. 2014;19(2 (85)):100-110. Available from: https://sid.ir/paper/78004/en

IEEE: Copy

M. HAGHBIN, M. ASKARZADEH, M. SHARIFZADEH, and M. SHABANI, “EVALUATION OF MEXILETINE EFFECT ON DURATION OF SENSORY AND MOTOR BLOCK IN SPINAL ANESTHESIA WITH LIDOCAINE,” ARMAGHAN DANESH, vol. 19, no. 2 (85), pp. 100–110, 2014, [Online]. Available: https://sid.ir/paper/78004/en

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