Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori

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TAGHIZADEH SOMAYYEH; FALSAFI TAHEREH; KERMANSHAHI ROUHA KASRA; RAMEZANI REIHANEH

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Journal: Galen Medical Journal Year:2020 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori

Author(s)

TAGHIZADEH SOMAYYEH | FALSAFI TAHEREH | KERMANSHAHI ROUHA KASRA | RAMEZANI REIHANEH | Issue Writer Certificate

Keywords

Gastric Epithelial Cell

Helicobacter pylori

Lactobacillus acidophilus

Lactobacillus rhamnosus

Macrophage

Abstract

Background: The present study aimed to evaluate the in vitro and in situ antagonistic effects of Lactobacillus probiotic strains on clinical strains of Helicobacter pylori. Also to investigate their immunomodulation effects on a Macrophage cell model. Materials and Methods: Anti-microbial effects of probiotic lactobacilli against H. pylori was assessed using the well and disk diffusion methods. Effects of lactobacilli probiotics strains, as well as their cell-free supernatant on adhesion of H. pylori to MKN-45 Gastric Epithelial Cells, were examined in their presence and absence. Immunomodulation effects of probiotic lactobacilli were performed using the U937 Macrophage cell model. Incubation of host cells with probiotics and their cell-free supernatants with cultured host cells was performed in different optimized conditions. The supernatant of host cells cultured in their presence and absence was used for cytokines measurement. Results: Two probiotics, Lactobacillus acidophilus ATCC4356, and Lactobacillus rhamnosus PTCC1607, could inhibit the growth of clinical H. pylori in vitro. They could also inhibit attachment of H. pylori to MKN-45 cells. Cell-free supernatant of L. acidophilus had a stimulating effect on the production of Interferon-gamma (IFN-γ ) by U937 cells. Conclusion: The present study demonstrates that, L. acidophilus ATCC4356 and L. rhamnosus PTCC1607 probiotic strains can inhibit the growth of clinical H. pylori in vitro. Treatment of U937 with alive H. pylori plus cell-free supernatant of L. acidophilus, have a significantly higher capacity to stimulate IFN-γ production than H. pylori alone. So, the metabolite (s) of this probiotic may have an immunomodulatory effect in immune response versus H. pylori.

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APA: Copy

TAGHIZADEH, SOMAYYEH, FALSAFI, TAHEREH, KERMANSHAHI, ROUHA KASRA, & RAMEZANI, REIHANEH. (2020). Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/780309/en

Vancouver: Copy

TAGHIZADEH SOMAYYEH, FALSAFI TAHEREH, KERMANSHAHI ROUHA KASRA, RAMEZANI REIHANEH. Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/780309/en

IEEE: Copy

SOMAYYEH TAGHIZADEH, TAHEREH FALSAFI, ROUHA KASRA KERMANSHAHI, and REIHANEH RAMEZANI, “Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/780309/en

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