THE EFFECTS OF TRETINOIN ON CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF THE MOUSE MODEL OF MULTIPLE SCLEROSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABTAHI FROUSHANI S.M.; DELIREZH N.; HOBBENAGHI R.; MORVARIDI A.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:4 (87) Page(s): 326-336

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,073

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF TRETINOIN ON CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF THE MOUSE MODEL OF MULTIPLE SCLEROSIS

Author(s)

ABTAHI FROUSHANI S.M. | DELIREZH N. | HOBBENAGHI R. | MORVARIDI A. | Issue Writer Certificate

Keywords

Not Registered.

Abstract

Background& aim: In spite of the progress achieved in the treatment of multiple sclerosis in recent years, many patients have been less responding than optimal to existing therapies. Previous studies have determined the immuno-modulatory potential of Tretinoin. The aim of the present study was to determine the effects of Tretinoin on the clinical and pathological features of multiple sclerosis mouse model.Methods: In the present study, experimental autoimmune encephalomyelitis was induced by immunization with MOG35-55 peptide and complete Freund's adjuvant in mice C57BL / 6. Infected mice were divided into two groups of 7 mice.7 mice were also used as controls. Tretinoin treatment (25 mg kg other day) was initiated as clinical signs appeared (day 12). Simultaneously, the control group received only the solvent. Symptoms were recorded daily until animals were slaughtered (day 33). In order to evaluate the neuropathology, the brain tissue was taken and sections were stained by hematoxylin and eosin and toluidine blue marquis methods. The data were analyzed by using Mann Whitney-U test.Results: Administration of Tretinoin after the onset of symptoms led to significant pain relief (p< 0.05). Histological findings showed decreased parenchymal edema, cellular infiltration and demyelization and degeneration of neurons in the brain were significantly reduced compared to control mice receiving Tretinoin (p<0.05).Conclusion: Tretinoin therapy, a useful strategy in the treatment of multiple sclerosis, should be considered.

Cites

No record.

References

Cite

APA: Copy

ABTAHI FROUSHANI, S.M., DELIREZH, N., HOBBENAGHI, R., & MORVARIDI, A.. (2014). THE EFFECTS OF TRETINOIN ON CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF THE MOUSE MODEL OF MULTIPLE SCLEROSIS. ARMAGHAN DANESH, 19(4 (87)), 326-336. SID. https://sid.ir/paper/78105/en

Vancouver: Copy

ABTAHI FROUSHANI S.M., DELIREZH N., HOBBENAGHI R., MORVARIDI A.. THE EFFECTS OF TRETINOIN ON CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF THE MOUSE MODEL OF MULTIPLE SCLEROSIS. ARMAGHAN DANESH[Internet]. 2014;19(4 (87)):326-336. Available from: https://sid.ir/paper/78105/en

IEEE: Copy

S.M. ABTAHI FROUSHANI, N. DELIREZH, R. HOBBENAGHI, and A. MORVARIDI, “THE EFFECTS OF TRETINOIN ON CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF THE MOUSE MODEL OF MULTIPLE SCLEROSIS,” ARMAGHAN DANESH, vol. 19, no. 4 (87), pp. 326–336, 2014, [Online]. Available: https://sid.ir/paper/78105/en

Related Journal Papers