EVALUATION OF GENE RS2623047 POLYMORPHISM OF HUMAN SULFATASE1 IN WOMEN WITH RECURRENT ABORTION COMPARED WITH WOMEN WITH NORMAL FERTILITY

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TAGHIZADEH E.; BAKHSHIGANJAE M.; TAGHIZADEH H.; BANIAMERIAN F.

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Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:3 (86) Page(s): 204-211

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Title

EVALUATION OF GENE RS2623047 POLYMORPHISM OF HUMAN SULFATASE1 IN WOMEN WITH RECURRENT ABORTION COMPARED WITH WOMEN WITH NORMAL FERTILITY

Author(s)

TAGHIZADEH E. | BAKHSHIGANJAE M. | TAGHIZADEH H. | BANIAMERIAN F. | Issue Writer Certificate

Keywords

POLYMORPHISMQ2

RECURRENT MISCARRIAGEQ2

SULFTASE1Q2

Abstract

Background & aim: RECURRENT MISCARRIAGE is defined as accruing of at least 3 clinical spontaneous abortions or more. Several factors including genetic and environmental factors are involved in it. Among them, SULFTASE1 gene rs 2623047 has a role in the human embryonic development. The purpose of this study was to evaluatesulftase1 gene rs 2623047 POLYMORPHISM in women with recurrent abortions referred to the infertility center of Yazd, Iran.Methods: In the present case-control study, sixty-five healthy women were selected as controls and thirty-five women with RECURRENT MISCARRIAGE were included as cases. B lood samples were taken from both groups manually, using a low-salt DNA extraction and amplified fragment POLYMORPHISM rs2623047 1 sulfatase gene madeby PCR and enzymic digestion conducted using BstNI enzyme. Results were analyzed using the chi-square test.Results: GG genotype in cases were 42±9% and in control group 5.18% respectively (p=0.003). While the AG genotype in the control group was 9.56% and in the cases 1.37% (p=0.003).Conclusions: Genetic variation in sulfatase 1 gene may have a role in embryonic development during pregnancy and larger studies with more samples along with other POLYMORPHISMs in this gene may be helpful.

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APA: Copy

TAGHIZADEH, E., BAKHSHIGANJAE, M., TAGHIZADEH, H., & BANIAMERIAN, F.. (2014). EVALUATION OF GENE RS2623047 POLYMORPHISM OF HUMAN SULFATASE1 IN WOMEN WITH RECURRENT ABORTION COMPARED WITH WOMEN WITH NORMAL FERTILITY. ARMAGHAN DANESH, 19(3 (86)), 204-211. SID. https://sid.ir/paper/78168/en

Vancouver: Copy

TAGHIZADEH E., BAKHSHIGANJAE M., TAGHIZADEH H., BANIAMERIAN F.. EVALUATION OF GENE RS2623047 POLYMORPHISM OF HUMAN SULFATASE1 IN WOMEN WITH RECURRENT ABORTION COMPARED WITH WOMEN WITH NORMAL FERTILITY. ARMAGHAN DANESH[Internet]. 2014;19(3 (86)):204-211. Available from: https://sid.ir/paper/78168/en

IEEE: Copy

E. TAGHIZADEH, M. BAKHSHIGANJAE, H. TAGHIZADEH, and F. BANIAMERIAN, “EVALUATION OF GENE RS2623047 POLYMORPHISM OF HUMAN SULFATASE1 IN WOMEN WITH RECURRENT ABORTION COMPARED WITH WOMEN WITH NORMAL FERTILITY,” ARMAGHAN DANESH, vol. 19, no. 3 (86), pp. 204–211, 2014, [Online]. Available: https://sid.ir/paper/78168/en

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