EFFECT OF MIR-146A AND MIR-150 ON T-CELL LYMPHOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS

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FALLAH P.; SOLEIMANI M.; HAMIDPOUR M.; REZAII TAVIRANI M.; GHAREHBAGHIAN A.; AREFIAN E.; AHMADI K.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2012 | Volume:9 | Issue:3 (36) Page(s): 186-198

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Title

EFFECT OF MIR-146A AND MIR-150 ON T-CELL LYMPHOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS

Author(s)

Keywords

MICRORNASQ2

MIR-150Q3

HUMANQ3

MIR-146A HUMANQ3

HEMATOPOIETIC STEM CELLSQ3

Abstract

Background and Objectives: Micro RNAs are a class of small non-coding RNAs which have been recently shown to play a crucial role in major cellular processes such as development and differentiation through posttranscriptional regulation. The role of these epigenetic elements has been also demonstrated in hematopoietic lineage differentiation and there is a large body of evidence that MIR-150 and miR-146a are responsible for T lymphocyte differentiation. Our goal was to examine the effect of MIR-150 and miR-146a overexpression in HEMATOPOIETIC STEM CELLS and its ability to differentiate these cells into a T lymphoid cell.Materials and Methods: In this experimental study CD133+ stem cells were employed as HEMATOPOIETIC STEM CELLS and permanent overexpression of MIR-150 and miR-146a was established. The differentiation progress was tracked by flowcytometry for lymphocyte markers such as CD4 and CD8.Moreover, expression of miR-146a and MIR-150 by RT-PCR and quantitative real time PCR after 7 days was studied.Results: The cells showed T lymphoid characteristics 7 days after transduction. CD4 and especially CD8 expression significantly increased.Conclusions: In conclusion, MIR-150 and miR-146a overexpression is an effective factor in T cytotoxic differentiation and they have the ability of directing CD133+ HEMATOPOIETIC STEM CELLS to express T lymphoid characteristics.

Cites

IN SILICO STUDIES REVEALED A CRUCIAL ROLE FOR MIR-146A ON PROGRESSION OF HELICOBACTER PYLORI INDUCED GASTRIC CANCER (REVIEW ARTICLE)

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APA: Copy

FALLAH, P., SOLEIMANI, M., HAMIDPOUR, M., REZAII TAVIRANI, M., GHAREHBAGHIAN, A., AREFIAN, E., & AHMADI, K.. (2012). EFFECT OF MIR-146A AND MIR-150 ON T-CELL LYMPHOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 9(3 (36)), 186-198. SID. https://sid.ir/paper/78320/en

Vancouver: Copy

FALLAH P., SOLEIMANI M., HAMIDPOUR M., REZAII TAVIRANI M., GHAREHBAGHIAN A., AREFIAN E., AHMADI K.. EFFECT OF MIR-146A AND MIR-150 ON T-CELL LYMPHOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2012;9(3 (36)):186-198. Available from: https://sid.ir/paper/78320/en

IEEE: Copy

P. FALLAH, M. SOLEIMANI, M. HAMIDPOUR, M. REZAII TAVIRANI, A. GHAREHBAGHIAN, E. AREFIAN, and K. AHMADI, “EFFECT OF MIR-146A AND MIR-150 ON T-CELL LYMPHOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 9, no. 3 (36), pp. 186–198, 2012, [Online]. Available: https://sid.ir/paper/78320/en

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